Studies On The Asymmetric Intramolecular Aldol Reaction Via Organo/Metal Cooperative Catalysis

With the rapid development of asymmetric catalysis, the asymmetric reactions via enantioselective desymmetrization have attracted much attention of many synthetic chemists. Substrates related to asymmetric desymmetrization mainly inludes meso-compounds and achiral compounds bearing prochiral stereocenters. Generally, such achiral compounds can be easily accessed, therefore the design of asymmetrical reactions via enantioselective desymmetrization has become one of the most important issues in asymmetric catalysis. Notably, the asymmetric intramolecular aldol reaction via desymmetrization has attracted considerable interest from many organic chemists.This theis mainly concerns about studies on the asymmetric intramolecular aldol reaction via organo/metal cooperative catalysis, in which the enantioselective desymmetrization was strategically involved. Our asymmetric catalytic intramolecular aldol reaction was presently realized under the catalysis of proline derivatives and Zn(OAc)2, and the reaction enantioselectivity could be reached up to 96% ee. Although the substrate scope and limitations remain to be further explored, the current results to some extent enrich the studies on intramolecular aldol reaction via enantioselective desymmetrization.