A Novel Of Near-infrared Long Afterglow Nanoparticles Were Synthesized And The Application In In Vivo Imaging

The applications of long afterglow luminescent materials have played an important role in human life and been developed dramatically in the past century for the unique and excellent luminescence properties. Especially the near infrared afterglow luminescent nano-materials, due to its the long duration of afterglow, capabibility of penetrating into deep level of biological organization and combination with functional groups (antibody, folic acid) to mark tumor cells and target recognition, will exhibit more extensive application for bioscience and clinical medicine in future. Although a variety of the long afterglow luminescent material have been developed and researched so mantel years, the reports of near-infrared long afterglow materials still remain more explorers.In order to develop and utilize the luminescence of near infrared nano-matericals better, in this paper, we introduced the novel near-infrared afterglow luminescent material as following:(1) The near infrared long afterglow material ofZn3Ga2Ge2010:Cr3+ was prepared by the solid-state reaction and the sol-gel method, respectively. The optical properties and morphologies of persistent phosphors were characterized by fluorescence spectra, excitation and emission spectra, afterglow spectra, afterglow decay curve and scanning electron microscope pictures.(2) The surface of near infrared long afterglow luminescent nano-material synthesized by sol-gel method was modified with functional group. The hydrophilicity and dispersion of the nano-materical were increased by chemical and physical methods, which make the materials widely used in biomedical applications furtherly.(3) The optical of modified near infrared long afterglow luminescent nano-material were further analyzed and discussed in vivo bio-imaging. Experimental results show that the material has high sensitivity properties in living organisms, deep organic organization, and could be repeatedly excited with a NIR light or laser. The images of the nano-materials achieve the permanent imaging. The applications of near-infrared afterglow nano-materials in vivo imaging show profound impact because of the detectable characteristic.