Solubility And Particles Formation Of Bicalutamide Using Subcritical Water Technology

The application of Subcritical water technology in improving the bioavailability of hydrophobic water insoluble drugs, active pharmaceutical ingredients was reported in this these. In this research work, the solubility and the nanoparticles generation of the class Ⅱ anti-cancer anti androgen bicalutamide oral drug were studied at temperature ranging from 110℃ to 180℃ and constant pressure of 5.5 MPa. The experiments were performed using a modify solvent anti solvent method combined with a subcritical water technology. The chemical and physical characteristics including the stability and the crystallinity of the processed drug samples was analysed under X-Ray Diffraction (XRD) Technique followed by Fourier Transformed Infra-Red (FTIR) Techniques. Statistical analyses were performed on the experimental data. The solubility data obtained were correlated using a modify Apelblat model. The Van’t Hoff equation was used to determine the thermodynamic parameters including the molar enthalpy (ΔHsol), molar entropy (ASsol), and the molar Gibbs free energy from the experimental solubility data.The nanoparticles were generated under various collection media temperatures and concentration conditions. Different pharmaceutical excipients/surfactants such as lactose monohydrate, polyethylene glycol, and sodium lauryl sulfate were used for the particles morphology, size and distribution control. The scanning electron microscopy (SEM) analysis was performed on the processed drug nanoparticles. The syntheses of nanoparticles up to 40 run with uniformity in morphology were achieved. The dissolution study of the synthesized nanoparticles drug was carried out. The size distribution analysis was also carried out using Image J software and the normal distribution was correlated using nonlinear (Gaussian function) fitting.The results of the predicted solubility show good agreement with the experimental values proving accurate dependency of solubility to the temperature. Important improvement in the size and morphology of the bicalutamide drug particles was achieved including enhancement in the bioavailability of the drug. The subcritical water technology has shown to be promising in developing pharmaceutical industries.