Study Of The Method For Degrading Fentanyl Compounds

Fentanyl compounds as a kind of potent narcotic analgesic have been widely used in clinical anesthesia in operation. When the concentration of fentanyl compounds in human blood beyond a certain value, the body would present some poisoning symptoms. Therefore, wasted fentanyl compounds produced by the production and application need to be imminent degraded. In this paper, the analysis and the degradation methodsof the fentanyl compounds were established. Commonly used degradation reagentswere investigated during the degradation of fentanyl compounds, and new sodium bromate mixed degradation reagent with high efficiency and low toxicity was developed. Morever, the methods for degradating the wasted solid or liquid fentanyl compounds were developed.1. The quantitative analysis of fentanyl compounds, such as entanyl, carfentanyl, sufentanyl and 3-methyfentanyl were established by gas chromatography. These methods exhibited well linear realationship, high accuracy and precision. Oxidation reaction was chosen as the most efficient degradation reaction type of fentanyl compounds among the different degradation systems, such as acid, alkali, nucleophilic and oxidative reactions.2. For the first time, three kinds of commonly used oxidation degradation reagents (i.e. caldium hypochlorite, sodium dichloroisocyanurate and sodium percarbonate) were employedin the degradation of fentanyl compounds. Fentanyl solution (1 g/L) could be totally degraded by these degradation reagents in 1 hour. Fentanyl solid on the surfaces of alkyd paint coating, iron, stainless steel and concrete (pollutant density of 1 g/m2) could be degraded by these degradation reagentsin 2 hours. Although they spent more time for the degradation, they still exhibited much ascendant in the spot degradation of fentanyl compounds, as they can degradate the fentanyl compounds absolutely, with no residue existing,3. The sodium bromate combined degradation systemwasfirst developed and usedin the degradation of fentanyl compounds.By optimizing the reaction conditions, the fomula was comfirmed, such as the molar ratio of sodium bromated/sodium bisulfite/sodium sulfite was 1:0.15:0.35, the molar ratio of sodium bromated to fentanyl was not below 50:1, and the pH was 3.9. Fentanyl solid on the different surfaces of alkyd paint coating, iron, stainless steel and concrete (pollutant density of 1 g/m2) could be 99.9% degraded by 0.6 L sodium bromate mixed degradation reagent in half an hour.The corrosivity of the mixed degradation reagent on stainless steel was low corrosion and the corrosivity of that on copper, carbon steel and aluminum were moderate corrosion.This method exhibited the characteristics of efficient, fast, cheap andlow corrosion, thus could be a suitable method for the practically environmental degradation of fentanyl compounds.