| Fosfomycin waste water is an antibiotic-type chemical wastewater. During the time, α- phenylethylamine as a resolving agent, split Propyl phosphonatewill be obtained fosfomycin.Due to a variety enrichment of amines, phosphoric acid substances.Fosfomycin pharmaceutical waste water COD of up to tens of thousands to hundreds of thousands mg/L, total phosphorus (TP) up to ten thousand mg/L, the high concentration of organic matter in waste water, is extremely difficult to degradation, microbial toxicity.lt is because of the difficulty of antibiotics pharmaceutical waste water big investment, high consumption, so many businesses antibiotics pharmaceutical waste water is not fully the case of timely and effective treatment, directly discharged to the municipal pipe network or near the river.These mixed with a lot of antibiotics pharmaceutical wastewater pollutants water environment, water ecology and a major threat to human health.Therefore, the use of different methods of antibiotic waste water and has become extremely urgent significance and practical value.This study was directed to the antibiotic fosfomycin pharmaceutical waste water treatment difficult characteristics, compared to the physical treatment, chemical treatment and biological treatment.Finally, selection method with CASS enhanced biological treatment of pharmaceutical waste water treatment process from the Northeast Pharmaceutical Factory.Three bacteria strains, which could effectively degrade fosfomycin sodium and phenethylamine have been screened and isolated from activated sludge of a pharmaceutical factory SBR(sequencing batch reactor) in north earth pharmaceutical of China. The strains were identified by 16SrDNA that N1 as Chryseobacterium, N2 and N3 as Proteus. Gradually increasing the concentration of fosfomycin sodium and phenethylamine,the degradation by three strains have been varied intensly. When the concentration of fosfomycin sodium was set up to 25ppm,the degradation by N1,N2 and N3 were 43.85%,35.05%,37.61%.And when the concentration was up to 50ppm, the degradation changed to 40.45%,36.54%, 30.91%. While the concentration had been increased to 75ppm, the degradation dropped greatly to 29.61%、10.75%.10.87%.Moreover,the growth of N2 and N3 have been badly limited as the growth of N1 have reached to its peak by degradation of 19.45%. The experiments of phenethylamine degradation have reached a similar result. When the concentration of phenylethylamine as 25ppm, three strains of degradation efficiency were 44.49%,47.83% and 47.81%, when the concentration of 50ppm, three strains of degradation efficiency were 23.35%,35.86%,39.91%, when the concentration of 75ppm, completely restrict the growth of bacteria N1, N2 and N3 and the growth of bacteria also produce a certain limit, the degradation efficiency of 19.27%,24.84% respectively. And at a concentration of 100ppm, the treatment effect N2 and N3 strains 12.36% and 19.92%. Appropriate proportion of N1 and N3 in the activated sludge to achieve a high efficiency degradation for those two contaminants need more research and this paper will provide a guidance for next work.By different proportions of fosfomycin and phenethylamine in simulated pharmaceutical waste water.In the case where COD=500 ppm, the test both substances were under the removal conditions 0%:100%,25%:75%,50%:50%, 75%:25% and 100%:0%.It can be found in 50%:50% of the optimal treatment effect was 53.67%.In the conventional activated sludge circulation system (CASS) reactor, adding degrading bacteria, for further processing anaerobic baffled reactor (ABR) after a comprehensive waste water pretreatment.Study on the pharmaceutical waste water of COD, ammonia, and TP related effect characteristic mechanism, while the generic drug sludge CASS reactor were compared.The results showed that adding degrading bacteria COD of 210.86 mg/L, ammonia was 19.49 mg/L, TP was 4.64 mg/L when, for COD, ammonia, TP average removal rates were 90.66%,91.15% and 85.51% better than 83.23% of the original activated sludge,84.16% and 70.31%.Therefore, the degrading bacteria in a 1:1:1 ratio was added to the reactor in actual treatment effect for COD, ammonia, TP and other indicators have improved significantly.And a performed by High Throughput method for the analysis of bacteria in the reactor, was found, up flora C1 reactor contents were bacteroidia 24%, β- Proteobacteria 23% and 14% of Bacillus subtilis. Added degrading bacteria C2 efficient mixing reactor contents were sphingobacterila 38%, β- Proteobacteria 24%, 12% is bacteroidia. Visible, have a significant impact on the populations of bacteria by adding efficient reactor after the bacteria, thereby affecting the processing efficiency. |
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