The Design Of Polydopamine-Based Nanocomposites And Application For Tumor Microwave Thermal Therapy

In recent years, it reals the advantages of new cancer therapies with the development of tumor hyperthermia, including simple treatment method, noticeably effective, side-effect-free and minimally invasive which named as’green remedy’. The microwave thermal therapy (MWTT) on the organism is in an endogenous way of heating, which has remarkable advantages, including high thermal conversion efficiency, deep puncture, uniformed hyperthermia fields, solidification zone necrosis completely and operability. MWTT has gradually become an important means for the treatment of tumor, and brings a ray of sunshine to cancer patients.Polydopamine (PDA) has become a research hotspot in recent years due to it is widely distributed in human and other living organisms, which owns many unique and excellent properties and extensively bioapplication, applications such as energy materials, sewage treatment, sensors, drug delivery. In particular, its excellent biocompatibility showed great application prospects in the field of biological medicine. In this paper, we design a kind of microwave sensitive material which has good biocompatibility, improve the efficiency of microwave heat transfer, and further improve the targeting of the treatment process. In order to realize the low power and high efficiency tumor microwave hyperthermia, we have taken the way of combination of MWTT and chemotherapy. The main work is as follows:(1) We use template method and physical filling method to systhetize polydopamine-coating ionic liquid (ILs). Compared with the ionic liquid in the free state, ILs/PDA nanocomposites show the microwave heating effect more quickly, more specific, more secure due to the confinement effect of PDA shell. In vitro and in vivo toxicity experiments showed their good biocompatibility. In addition, ILs/PDA nanocomposites were applied in ICR mice model in vivo for microwave hyperthermia, the results showed that the tumors in treatment group could be suppressed effectively, and ILs/PDA nanocomposite exhibited obvious targeting with intravenous injection.(2) The ILs/PDA nanocomposites were as precursor, physical shock method was applied in the synthesis of the ionic liquid-polydopamine-doxorubicin (IL-PDA-DOX) nanocomposites and provided a treatment platform for combined chemotherapy and microwave thermal therapy of cancer. In vitro experiment proved that material had microwave sensitization performance. The safety of materials was evaluated by in vivo and in vitro toxicity test. By reducing the power of microwave hyperthermia, the IL-PDA-DOX nanocomposites were applied to the ICR mice model in vivo and obtained excellent antitumor effect.