Synthesis Of Novel Pyrrole Derivative And Fabricated To Drug Sensor

A novel pyrrole derivative (3-pyrrolyl-1-yl-propyl)triethylammonium iodide (A3) was chemically synthesized and purified successfully, and electrochemical polymerized on to the surface of glassy carbon electrode (GCE) to construct GCE/polyA3. The optical conditions of A3 polymerization were:modified with 10 μL of 4 mg/mL A3 solution, the scan potential range was controlled between 0 and 0.9 V vs. SCE for 25 cycles with the scan rate of 100 mV/s, and 0.1 mol/L LiClO4 was used as the electrolyte. Cobalt hexacyanoferrate (CoHCF) was electrochemical synthesized and modified with GCE/polyA3 to construct a drug sensor (GCE/polyA3-CoHCF) for paracetamol. The results show that the sensor increased redox current of paracetamol, while the redox potential was increased as well.Based on the above research results on poly A3, pyrrole derivative was further improved: (11-pyrrolyl-1-yl-undecyl)triethylammonium tetrafluoroborate (A2) was electrochemical polymerized on the surface of GCE combined with single wall carbon nanotubes (SWCNTs) to construct GCE/polyA2/SWCNTs. The tetrafluoroborate was ion-exchanged with Fe(CN)63-/Fe(CN)64- to construct a novel drug sensor (GCE/polyA2-Fe(CN)63-/4-/SWCNTs). The electrochemical ability and redox reaction mechanism were investigated by cyclic voltammograms, differential pulse voltammetry and amperometry, respectively. GCE/polyA2-Fe(CN)63-/4-/SWCNTs showed an excellent electrocatalytic activity for paracetamol at 0.4 V vs. SCE, and the fast response was proportional to paracetamol concentration in the range of 3.39×10-7～7.98×10-4 mol/L with a detection limit of 6.9× 10’8 mol/L (S/N=3). The results also suggest that the drug sensor had an excellent sensitivity for determination of paracetamol in real samples (in serum/urine).