Studies On Copper- And Iron- Catalyzed Coupling Reactions Of Acyl/Alkoxycarbonyl Radicals With Amino Compounds

Amide derivatives are an important kind of compounds, which are widely found in nature, and it can be used as medicine and pesticide. Carbamate derivatives are another important compounds with a variety of physical activity, which often are used as pesticide and pharmaceutical, at the same time, it is an important intermediate for organic synthesis.This thesis is divided into two parts. The first part involves iron-catalyzed coupling reaction of acyl radicals with amine to give derivatives of amide. The reaction is highly regioselective and products were obtained in good yields. The second part involves copper-catalyzed coupling reaction of alkoxycarbonyl radicals with amine to afford amino acid esters in good yield. The reaction involves simple manipulation and proceeds under mild conditions with good regioselectivity.The structures of synthesized compounds were confirmed by 1H NMR, 13 C NMR and HRMS spectra. On basis of results obtained, plausible mechanisms were proposed for these reactions.