Ionone Site Selective Oxidation Reaction Study And Vinyl Phenol Oxidation To Dearomatization Reaction

In the study for the synthesis of natural products. there are many intermediates that need to be prepared from oxidation reaction. for instance:in the plant hormone abscisic acid synthesis process, Selective epoxidation ionone has a key role in the synthesis of abscisic acid process. In addition. indole and indole lamictal are skeleton structures that widely existed in natural products and drugs. By oxidation to the aroma of this special oxidation means, quickly build this type of skeleton has a very important significance in drug synthesis.1. Synthesized and screened through a series of different steric, different electrical properties of organic selenium catalyst to achieve selective oxidation ionone different sites. with a yield of 72% of the epoxide product obtained is selectively ionone. It provides a methodology to ensure efficient synthesis of abscisic acid, The catalyst can be recycled, which is a potentially environmentally friendly method for the synthesis of key intermediates ABA.2. High catalytic oxidation of iodine explore vinyl aromatic phenol to the reaction, In order to quickly build a skeleton structure indole indole-triazinc, This protocol required no transition metal catalysts and 30 of such derivatives were synthesized in a yield of up to%. dr value of up to 20:1. Using this method can efficiently build a Class skeleton structure indole and indole-triazine.3. Based on the oxidation of phenol by hypervalent iodine. to implements some alkaloids similar skeleton modification and conversion. resulting in six different compounds. All structures were desired product by IR.1H-NMR.13C-NMR. GC-MS spectra.