Research On The Stopper Of The Potting Syringe And The Micropore Stopper

In this paper, bromobutyl rubber plungers for prefilled syringes and microcellular stopper were developed. In the first part, effect of the filler system on the properties of BIIR compound, the hot aging properties of BIIR compound, and life prediction of BIIR compound in saline solution were investigated. In the second part, the microcellular foams were fabricated by batch foaming method and using N2 as the foaming agent, and exploring the feasibility of its application in microcellular stoppers.In the research of the stopper on prefilled syringe, the effect of the kaolin/talcum powder blend ratio on BIIR compound of the stopper was discussed, the dispersion of the filler in the compound was characterized by the scanning microscope(SEM) and rubber processing analyzer(RPA). The results showed that the Mooney viscosity of the compound decreased if BIIR was filled with only kaolin or talcum powder, which had good plasticity and excellent processability; however, with two kinds of filler, the plasticity and processing performance was reduced. The two kind filler was filled the compound, which had the improvement of the physical properties and better dispersion. And when the ratio of the kaolin/talcum powder was 75/15, the compression set was better. For the aging of the stopper rubber with the method of the laboratory accelerated aging, the results indicated that the physical properties of the stopper rubber were decreased with the aging time and temperature increasing. The compression set as the evaluation standard, the life prediction in physiological saline of the stopper was about 3.8 years.In the research of the microcellular stopper, BIMSM and BIIR/OBCs microcellular foaming materials were fabricated by pressure-quench method and using N2 as foaming agent. The cell morphology was characterized by SEM the cell size was analysised with the ImageJ software. The effect of kaolin content and foaming temperature on the foaming properties and physical properties of BIMSM microcellular foaming materials was investigated; the effect of BIIR/OBCs blend ratio and foaming temperature on the foaming properties and physical properties of BIIR/OBCs microcellular foaming materials was also discussed. The result showed that the foaming density, hardness, tensile strength and tear strength of BIMSM microcellular foaming materials were increased with the content of kaolin increasing. The foaming temperature was higher, the cell structure was better. The cell size of BIIR/OBCs microcellular foaming materials at the condition of 100℃ and 18 MPa was decreased by the DCP content increasing And as the content of OBCs increasing, the average cells size of BIIR/OBCs microcellular foaming materials was decreased at the condition of 120℃ and 18 MPa. The foaming density, hardness, tensile strength all showed the increasing trend.