Studies On I₂-catalyzed Methodologies For The Synthesis Of Diarylquinoline Derivatives

In this paper, a metal free I2-catalyzed cyclization of quinoline derivatives between enamides and imines has been developed. This approach is available for a broad range of substrates and provides an extremely simple and efficient way to construct heteroaromatic quinoline derivatives in moderate to good yields. The article is divided into the following three chapters:Chapter one : Summarizing the chemical properties and the practical applications of quinolines. The quinoline core is found in a large number of natural products, many of which have important biological activities and potential pharmaceutical applications. The readily applications of quinolines are wildly applied in the industry of new materials, pharmaceuticals and agriculture etc.Chapter two:Reviewing the advances in synthesis of quinoline derivatives. The synthesis of substituted quinolines has been a subject of great focus in organic chemistry, as a result, various classic methods in synthezing quinolines hane been generated. Recently, in the field of green chemistry, many highlight researches in the synthesis of quinolines using approaches like microwave-mediated, UV-mediated, ultrasonic-mediated and metal-free-mediated have been found and well-explored.Chapter three:Studies on methodologies for the synthesis of 2,4-diarylquinoline derivatives. Recently, molecular iodine has received considerable attention as a readily available catalyst for various organic transformations, affording the corresponding products in excellent yields. Inspired by the previous works on the formation of substituted quinolines, we report a concise approach to substituted quinolines from enamides and imines catalyzed by iodine under air. Compared to former reported access to quinoline derivatives, this approach has advantages on extremely simple procedure with less reaction time, mild reaction conditions, accessible to various substrates, high catalytic efficiency etc.