Development Of The Intelligent Dissolution Tester

In drug testing, the dissolution of the active pharmaceutical ingredient from thetablets, capsules or granules preparation under specified conditions the rate and extentof dissolution.It is to evaluate the pharmaceutical solid oral preparation of a qualityindicator, is an analog of oral solid preparation in the gastrointestinal tract in vitrodisintegration and dissolution test method simple.Dissolution method is to put acertain amount of a formulation of the rotating basket dissolution apparatus(dissolution cup) in37℃±0.5℃at a constant temperature, at a predeterminedrotational speed, according to the operation of dissolution medium at predeterminedtime are sampled and tested for dissolution.Dissolution instruments is for thedetermination of the dissolution test apparatus is provided a method.First, the impact of the dissolution of the main factors include the accuratemeasurement of the motor speed control and temperature accuracy.Second, with the industrial process automation increasing levels of measurementinstruments in real-time, accuracy, availability and other aspects of higher demand.Based on the analysis of past dissolution tester works, the measurement processand deal with the problems facing the problem, based on the elimination ofelectromagnetic interference devices, microcontrollers work to improve efficiency,enhance the stability and accuracy of the temperature acquisition and operatingpracticality and so do the corresponding innovation, developed a new type ofdissolution tester.First, the hardware circuit design, based on intelligent micro controller hardwaredesign of peripheral circuits, including the power circuit, the temperature signalacquisition circuit, the motor control circuit, the human interface and communicationcircuit.Secondly, the system software design, including temperature acquisitionsubroutine, motor control subroutine, the key input routines, display output sublyimproved.Finally, and in the past used to compare dissolution tester, in real time,measurement accuracy and stability, integration has greatly improved.