The Relationship Between The Serum Osteopontin Level And Survival Time And Prognosis In Patients Of Non-Small Cell Lung Cancer

Objective Independent testing the content of Osteopontin (OPN) in the peripheralblood in patients with non-small cell lung cancer (NSCLC). Exploring the relationshipbetween the serum osteopontin level and survival time and prognosis in patients withnon-small cell lung cancer. Judging serum OPN whether as an independent indicators topredict prognosis in patients with non-small cell lung cancer.Method It applies Enzyme Linked Immunosorbent Assay (ELISA) to detect theperipheral serum OPN levels of114NSCLC patients,62benign lung disease patients and40healthy people. SPSS11.5statistical software is used for statistical analysis, with P<0.05being considered statistically significant. By using T test and non-parametric tests, it analyzesthe relationship between serum OPN level and NSCLC’s various clinical factors.Kaplan-Meier method is also used to make survival analysis and draw the survival curve. Coxregression model is applied to analyze the relationship between relevant factors such as theserum OPN level and the prognosis of NSCLC patients.Results (1) The Serum OPN levels are significantly different between the patients ofNSCLC and benign lung disease and healthy group (P<0.05). However, there are nosignificant differences between the Serum OPN levels of lung benign disease group andhealthy group (P>0.05).(2) There are no significant differences between the Serum OPNlevels and patient’s gender, age, and pathological type (P>0.05), but with NSCLC’s clinicalstage, lymph node metastasis and distant metastasis (P<0.05).(3) Serum OPN levels havelinear correlation with clinical stages.(4) The survival time of patients with high serum OPNlevel is shorter than those with lower serum OPN level. A clear correlation between clinicalstages, lymph node metastasis, distant metastasis and the level of serum OPN with survival time has been detected (P<0.05).(5) Combined with follow-up survey data of patients, themultifactor survival analysis of Cox regression mode reveals the significant correlation amongclinical stages, lymph node metastasis, distant metastasis and prognosis of patients (P<0.05),which are also the risk factors affecting the prognosis. However, serum OPN level cannot beconsidered as the unique risk factor to determine the prognosis.Conclusions (1) The Serum OPN level of NSCLC patients is significantly higher,which can be used as the identification indicator of lung cancer’s status as benign ormalignant and even can be used as a detection indicator of lung cancer diagnosis.(2) SerumOPN level has no relationship with patient’s gender, age, and pathological type, but withNSCLC’s clinical stages, lymph node metastasis and distant metastasis, which suggests that ahigh level OPN may be associated with lung cancer invasion and metastasis.(3) For the patientsconfirmed with the NSCLC, serum OPN level has important reference value for judging the malignancydegree of NSCLC, clinical stage and metastasis.(4) A single measurement of serum OPN level cannotbe considered as the unique risk factor to determine the prognosis.