Relationship Between Trace Element Zinc, Serum Leptin Level And Metabolic Syndrome In Old Urban Residents

Objective To explore the relations between trace element zinc, blood leptin level andmetabolic syndrome in old urban residents of Yinchuan, and to provide scientific guide forprevention and treatment metabolic syndrome.Methods Selected120cases of elderly patients with metabolic syndrome and healthywho conformed diagnosis, inclusion and exclusion criteria in the communities. All subjectswere using the general sociological questionnaire,lifestyle and eating habits questionnaire,24hdietary recalls questionnaire survey to research. And detection the routine physical examinationof height, weight, blood pressure and fasting blood glucose, blood lipids (total cholesterol,triglycerides, low density lipoprotein, high density lipoprotein). Determination the serum traceelements zinc levels by ICP-OES. Determination the serum leptin levels by enzyme-linkedimmunosorbent assay (ELISA).Results (1)The mean age of subjects were67.90±5.89years old. No significantdifferences of gender, age, ethnicity, general information and lifestyle among MS group andcontrol group. Meat and vegetables cooking methods were different among tow groups,thedifferences were statistically significant(p<0.05).(2) BMI、SBP、DBP、FPG、TC、TG andLDL-C of MS group were higher than control group, and HDL-C of MS group were lowerthan control group, the differences were statistically significant(p<0.05).(3) Dietary traceelements zinc and serum trace elements zinc of MS group were lower than the control group,and serum leptin levels of MS patient higher than that in the control groups,the differenceswere statistically significant(p<0.05).(4)The level of serum trace elements zinc was negativelycorrelated with BMI,SBP,DBP, FPG,TG,and was positively correlated with HDL-C,and was no correlated with TC,LDL-C and LEP.(5) The level of serum leptin was positively correlatedwith BMI,SBP,DBP,TC,TG,LDL-C and was no correlated with FPG,HDL-C.(6)Serum traceelements zinc was divided into three levels.BMI,SBP in the low-levelgroup,middle-levelgroup and high-level group radually decreased was corrected by one-way ANOVA. HDL-Cof middle-level group higher than the low-level group,and the MS prevalence was significantdifference between above three groups,the differences were statistically significant(p<0.05).(7)The level of serum leptin was divided into three levels.LEP,BMI,SBP in the low-level group,middle-level group and high-level group radually increased was corrected by one-wayANOVA. DBP of middle-level group below the low-level group, HDL-C of middle-level group higher than the low-level group, and the MS prevalence was significant differencebetween above three groups,the differences were statistically significant(p<0.05).(8)The prevalence of metabolic syndrome as the dependent variable(No=1,Yes=2). Univariateanalysis showed that high LEP,obesity, hypertension,diabetes, high TC, high TG and lowHDL-C are independent risk factors for MS. High Serum trace elements zinc level and meatcooking method are the protective factors in the MS.(9)Multiple non-conditional logisticregression model analysis showed that Obesity, hypertension,high TC, high TG, low HDL-Cof MS risk factors and that high serum trace elements zinc level is protective factors.Conclusions Relationship between trace elements zinc, MS and its related metabolicdisordersare are closely. Zinc may be an aprotective effect for MS. Zinc nutritional status ofold urban residents in Yinchuan is poor.The MS patients with zinc deficiency situation is moreobvious.Relationship between leptin, MS and its related metabolic disordersare are closely.High serum leptin levels may be related to the prevalence of MS and its related metabolicdisorders. The relationship between trace elements zinc and leptin is not clear.We the need forfurther research and feasibility studies to know.