A Case-control Study On Occurring Correlation Factors Of The Re-treatment Multidrug Resistant Pulmonary Tuberculosis In5Prefectures In Zhejiang Province

Objectives:To explore the occurring correlation factors on patients with re-treatment multidrug resistant pulmonary tuberculosis (MDR-TB) in the5prefectures of Programmatic Management of Drug Resistant Tuberculosis(PMDRT) project supported by The Global Fund to Fight AIDS, Tuberculosis and Malaria(GFATM) in Zhejiang Province.Methods:A case-control study was carried out in the5prefectures of PMDRT project in Zhejiang province, in which118re-treatment multidrug resistant pulmonary tuberculosis patients were enrolled, who were diagnosed from March1,2010to October31,2011period, and81re-treatment non-MDR-TB patients were taken as control meanwhile. And a questionnaire investigation was conducted to explore the occurring correlation factors of re-treatment MDR-TB. The obtained data was analyzed to explore the correlation factors by non conditional Logistic regression which was based on the univariate analysis, and the adjusted odds ratios (OR) and the confidence interval (95%CI) was used to evaluate the effect size.Results:1.There were118re-treatment MDR-TB patients and81re-treatment non-MDR-TB patients were enrolled. There were75.42%and81.48%males in case group and control group respectively. Age distribute mainly in20-59age group, were70.34%and75.31%respectively. They were mainly household local, respectively67.54%and66.22%. Ethnic Han and married mainly,97.46%,76.27%and98.75%,77.78%, respectively. There was no significant difference in general characteristics between case group and control group, such as gender, age, nationality, residence, region and marriage status.2.Univariate analysis showed:the sick time, the antituberculous treatment time, the number of treatments anti tuberculosis, the rate of adverse reactions, and the number of interruption were higher in cases than those in control group, definite time required for cases to be shorter than control group, and the difference was statistically significant (P<0.05).3.The7factors with p<0.1in the univariate analysis were taken into a multivariate Logistic regression analysis, and2factors were incorporated into the model eventually:Adverse reactions during treatment, The umber of treatments anti tuberculosis(≥3),and their adjusted OR and95%Cl respectively were:7.70(1.96,8.64) and6.25(2.33,16.78).Conclusions:The mainly occurring correlation factors of the re-treatment MDR-TB in the5prefectures were:Adverse reactions during treatment, The number of treatments anti tuberculosis(≥3).It’s necessary to strengthen the standardized treatment for smear-positive pulmonary tuberculosis patients, treat the adverse reactions timely, improve their treatment compliance, and reduce the number of interruption, so as to reduce the incidence rate of retreatment MDR-TB ultimately.