Clinical Study Of Relationship Between The Severity Of Cor Onary Artery Lesions And Impaired Glucose Regulation

Objective：The results of previous study show that diabetes mellitus is the risk factor forcoronary heart disease (CHD), but relationship between impaired glucose regulation andseverity of coronary artery lesions should be clarified. The purpose of the study is to offerhelp for the design of treatment programs in patient with serious coronary artery lesionscomplicated with impaired glucose regulation through research relationship betweenimpaired glucose regulation and severity of coronary artery lesions.Method：This study included101cases of suspected coronary heart disease underwentselective coronary angiography (CAG). There of42patients with normal glucose and59patients with impaired glucose regulation according to fasting glucose and postprandialglucose. All subjects underwent assessment of the degree of coronary artery lesions andcollected clinical data. The degree of coronary artery lesions were compared between twogroups and multivariate analysis was used.Results：The group of impaired glucose regulation showed significantly higher rate of selective coronary angiography (61.9%vs94.9%，P<0.001) and a significantly higher rate of multiple vessel disease（81.4%vs28.6,P<0.001） when comparedto controls. There was significant difference in the scores of Gensini between group of impaired glucose regulation (medians:68.0) and group of normal glucose(medians:9.5)(P<005). There was significant difference in the rate of degree ofcoronary artery lesions between group of impaired glucose regulation (mild lesions:10.2%, moderate lesions:13.6%, severe lesions:76.3%) and group of normal glucose (mild lesions:78.6%, moderate lesions:16.7%, severe lesions:4.8%)(P<0.001). There was significant difference in the rate of mild lesions and severe lesions between two group (P<0.001). There was no significant difference in the rate ofmoderate lesions between two group (P<0.001). Multivariate analysis revealed fasting glucose and postprandial glucose to be independent predictors of multiple vessel disease and severe lesions.Conclusion：Impaired glucose regulation is independent risk factor for coronary heartdisease, multiple vessel disease and severe lesions. In addition, the influence of impairedglucose regulation on the coronary artery severe lesions is fully considered and design oftreatment programs.