Design, Synthesis And Biologicalactivity Studies About Polyoxometalates Based Compound

Objective The aim of this thesis is to synthesize novel polyoxometalates （POMs）based compounds and investigate the relations between structures and activities. Theirstructural characterization and biological properties are also carried out.Methods All these compounds have been isolated by hydrothermal methods andstructurally characterized by single crystal X-ray diffractions （XRD）, X-Ray powderdiffraction （XRPD） patterns, elemental analyses （EA）, thermogravimetric analysis（TGA） and IR. The interaction between compounds and DNA is carried out by IR.Moreover, the antitumor activities in vitro were studied by MTT experiments and theantibacterial activities of the complexes were tested by the paper disc method.Results Four compounds based on POMs have been synthesized by introducing organicmolecules. Interestingly, compounds displayed the ability of interaction with DNA byinvestigating the effective modification and association constant. In addition, the results of theantitumor activity in vitro showed that the different structures of the complexes exhibiteddifferent antitumor activity and selectivity on tumor cells.Conclusions In this paper, nolvel organic-inorganic hybrid compounds based on POMsand quinolones drugs have been synthesized by utilizing pipemidic acid or heterocyclicmolecular of tetrazoline as organic ligands. Organic ligands modified POMs building block unitby coordination bond or intermolecular interaction in the presence of transition metal ions. Toexplore the synthetic conditions and rules for quinolones-modified POMs-based compounds,and to study the relationships between microstructures and nature of the compounds, four neworganic-inorganic hybrid compounds have been prepared.{[Cu（PPA）2]2[H3PMo12O40]}·8H2O （1）；{[Zn（PPA）2][H3PMo12O40]}·[HPPA]·3H2O （2）；{[Zn（HPPA）2H2O]2[H2ZnW12O40]}.9H2O （3）；[Ag3（pytz）2（H2O）]2·[HAgGeMo12O40]·H2O （4）。 The ultraviolet spectrogram demonstrated that compounds1-3display strong interactiveability with DNA, and the combination pattern of compounds and DNA turn out to beintercalative interaction.The results of antitumor activities experiments of compounds show thatthere are multipule factors influencing the antitumor activities of these compounds, such as thecharacteristic feature of drugs molecular and coordination mode of POMs. That is, thesynergistic effect of POMs and drugs molecular adjusted the antitumor activities of compounds.In particular, metal ions play a key role in the electron transfer between POMs and metal-organic complex. In addition, the results of antibacterial activity experiments of compounds1-4indicate that all compounds possess the property of inhibiting effect on staphylococcus aureusand escherichia coli. Furthermore, by inspection of the antibacterial activity of compounds1-4,it is believed that the all compounds possess the property of inhibiting effect on staphylococcusaureus and escherichia coli by inheriting form Ag ions and pipemidic acid. The present workopens a promising approach to design POMs-based solid-state materials for antibacterial.