The Expression Of TIMP2and STAT3in Gastric Carcinoma And Its Clinical Significance

Objective To study the expression level of TIMP2in gastric cancer tissues and bymonitoring the expression of STAT3, TIMP2and STAT3in gastric carcinoma andthe relationship between them, to explore the biological significance in gastriccancer.Methods Immunohistochemical expression of TIMP2in60cases of gastriccarcinoma and STAT3were measured, understanding the relationship betweenTIMP2and STAT3expression and clinical pathological indexes, and the correlationbetween expression. Statistical methods: SPSS version17statistical software toanalyze the results. According to the material properties usingχ2test, Spearman test,Wilc-oxon test and Kruskal-Wallis method, P <0.05had significant differenceResults The expression of TIMP2, STAT3in gastric cancer cells, partly in thecytoplasm surrounding stroma and membrane. In normal gastric tissue, mainly ininflammatory cells and interstitial cells. The expression of TIMP2and STAT3ingastric carcinoma: the positive cells of TIMP2and STAT3staining showed diffuseand in the organization (or) scattered, the TIMP2staining was mainly in tumor cellnuclei or cytoplasm. Cytoplasmic STAT3localization in tumor cells,15cases ofnormal tissue TIMP2and STAT3had no expression; TIMP2and STAT3in15casesof paracancerous tissue expression rates were20%(3/15) and26.67%(4/15); thepositive expression in60cases of gastric cancer tissues were75%(45/60) and70%(42/60). Expression of both in normal, cancer, cancer is increasing, and the cancerand adjacent tissue compared with normal tissue, cancer tissue, the difference was statistically significant (P <0.05). Expression was positively correlated with TIMP2and STAT3in gastric carcinoma two.Conclusion The overexpression of TIMP2and STAT3in gastric cancer tissues,showed their relation with gastric cancer is very close. TIMP2, STAT3in gastriccarcinoma and the depth of tumor invasion, stage were positively correlated, TIMP2,STAT3expression was positively correlated, suggesting that both may indirectlyinhibit and promote the occurrence and development of gastric cancer invasion andmetastasis, which plays a role in.