Expression And Significance Of AR And Mda9/syntenin In Triple Negative Breast Cancer

Objective: Triple negative breast cancer（TNBC） is defined lack of estrogen receptor（ER）,progesterone receptor (PR) and human epidermal growth factor receptor2（Her-2）,it had special biological characteristic，include highly invasion,rapidlyprogress and lack of targeted therapy-like HER2blocking agents or hormonal therapy.Syntenin as a PDZ domain containing scaffold protein, plays a role in a variety ofoccurrence and metastasis of tumors.Androgen receptor(AR) may be a potential prognosticmarker in breast cancer.but in some preclinical study androgen receptor(AR) playcontroversial role,can stimulate or inhibite a variety of breast cancer cell lines.This studyanalyzed the correlativity between expression level of AR and syntenin andclinicalpathological parameters in the triple negative breast cancer（TNBC）,to attempt toFind a new potential prognostic maker of triple negative breast cancer（TNBC）.Methods: To measure the expression level of AR and syntenin by immunohistochemistryin80cases of triple negative breast cancer, and discuss relationship between the twoprotein and clinicalpathological parameters,and use Kaplan-Meier survival curves toevaluate disease free survival of the patients,at the same time use COX proportion regressmodel to multivariate analysis.Results: AR expression was identified immunohistochemically in30of80(37.5%) ofTriple negative breast cancer，while50of80(62.5%) is negative;79of80(98.8%) weresyntenin positive,and that1of80were syntenin negative in my specimen.A negativecorrelation between androgen receptor(AR) expression and tumer grade was significantly（rs=-0.236，P=0.035）,however androgen receptor(AR) had no relation with tumer sizeand lymph node status（P>0.05）; Syntenin expression was positively correlated with tumergrade（rs=0.230，P=0.04）、tumer size （rs=0.370，P=0.001）and lymph node status （rs=0.296，P=0.008）; The results indicated DFS was correlated with tumer size andlymph node status(P<0.05),however it had no relation with AR,syntenin, age andhistological grade(P>0.05).Conclusion: The expression level of AR and syntenin is related to clinicalpathologicfeatures,but whether it will need further study the two protein as new prognostic factors.