Discussion The Clinical Significance Of C-reactive Protein And Fibrinogen Detection In Lung Cancer

Objective：To explore the association between the C-reactive protein(CRP), fibrinogen(FIB)and the incidence of lung cancer as well as clinicopathologic features in patients withlung cancer.Method：Collect the Second Affiliated Hospital of Nanchang University in September2012to September2013were first treated123cases of newly diagnosed lung cancerpatients (lung cancer group) and the same period115cases of hospitalized patientswith common chronic respiratory disease in instable period (control group), Detectionthe peripheral blood CRP, FIB, erythrocyte sedimentation rate (ESR),carcinoembryonic antigen (CEA), white blood cell count (WBC) levels in all patients.Application of t-test and nonparametric-test to compare the differences of theparameters between two independent samples,while analyzed the relationship withthe incidence of lung cancer and the the clinicopathological features in patients withlung cancer by logistic regression.Result：According to the t-test and nonparametric-test results showed:compared withpulmonary benign lesion group,blood CRP and FIB, ESR, CEA levels increase inlung cancer group has statistical significance(P<0.01). However the Logisticregression analysis in the incidence of lung cancer:the level of plasma FIB increaseassociated with the incidence of lung cancer significantly(P<0.01,OR2.79,95%CI1.29~6.03),while the rise of serum CRP level and the incidence of lung cancer has noobvious correlation(P=0.96,OR1.02,95%CI0.48~2.17). In the NSCLC, research onthe relationship between the clinical clinicopathologic features of patients and serumCRP,as well as blood plasma FIB, Chi-square test results shows: gender (P=0.020),with or without smoking history(P=0.013),tumor staging (P=0.022) and patients withelevated CRP levels were significant correlation, but age(P=0.162),tumor pathologic classification (P=0.236),the degree of tumor differentiation (P=0.622) in patients withelevated CRP levels has no significant association, along with the Logistic analysis,the results showed the tumor staging and age were independent factors of the NSCLCpatients with elevated serum CRP levels(P=0.007). However regarding the elevatedplasma FIB level, whether it is the Chi-square test or Logistic regression analysis hasnot been found that the relationship between clinicopathologic features of NSCLCpatients and elevated plasma FIB levels is significant correlation, similar,theclinicopathologic features are not an independent factor of the NSCLC patients withthe elevated plasma FIB. The limitation of the lesions and extensive lesions inpatients with SCLC, whether the raised serum CRP level or the increased plasma FIBhad no statistically significant differences in the twogroup(P=0.08,P=1.00,respectively).Conclusions:Elevated serum CRP levels may be associated with the incidence of lung cancer,and is closely related to the clinical stage of non-small cell lung cancer. The increasedplasma FIB levels is closely related to the incidence of lung cancer.