Predictive Value And Correlation Analysis Of Ventricular Arrhythmias Via Heart Rate Variability In Patients With Structural Heart Disease

Objective: To observe the relationship between the ventricular arrhythmias andheart rate variability in patients with structural heart disease by studying of heart ratevariability (SDNN in the time-domain analysis and sympathetic/vagal ratio in thefrequency domain analysis) via ambulatory electrocardiogram monitoring.Methods: Three hundreds patients were collected from Jiangxi Province PeopleHospital in the period of March2012and October2013, whom were underwent24-hour ambulatory ECG. Then, RR interval of normal sinus beat (SDNN) wascalculated automatically and the indexes of time domain and frequency domain (HF,VLF, LF/HF) was collected. The valve of sympathetic/vagal was got from thethree-dimensional analysis power map for24hours by special software. According toHolter test results, all patients was divided into four groups: SDNN>100ms (groupA,74cases) and SDNN <100ms (group B,62cases) without structural heart disease;SDNN>100ms (group C,50cases) and SDNN <100ms (group D,114cases) withstructural heart disease. The data was statistical analyzed among the different groups;In addition, all the patients with structural heart disease and ventricular arrhythmiaswas divided into four groups: group A1,(without ventricular arrhythmias, andwithout structural heart disease group,122cases), group B1(with ventriculararrhythmias, but without structural heart disease group,14cases), group C1(withoutventricular arrhythmias, but with structural heart disease group,109cases), groupD1,(with ventricular arrhythmias, and with structural heart disease group,55cases).Relevant data was statistically analyzed to compare with each group of sympathetic/vagal ratio difference; SDNN and sympathetic/vagal ratio correlation using spearsoncorrelation analysis;Results: Compared to control group, the incidence rate of ventriculararrhythmias increases significantly in the Structural heart disease with SDNN<100ms group (39.5%vs4.1%; P<0.01); and the sympathetic/vagal ratio ofstructural heart disease with ventricular arrhythmia group was significantly higherthan control group (19.9±2.3vs10.1±1.7; P<0.01). Time domain (SDNN) and frequency domain (sympathetic/vagal ratio) were negatively correlated (r=-0.819, p<0.01).Conclusions:1. The incidence of ventricular arrhythmias increased significantlyin the patient with structural heart disease and SDNN <100ms， The incidence ofventricular arrhythmias probably increased significantly in the patient withSympathetic/vagal ratio higher and structural heart disease；2. Time domain (SDNN)and frequency domain (sympathetic/vagal ratio)have good correlation，SDNN<100ms and increase of sympathetic/vagal ratio can be considered as ventriculararrhythmias predictors in patients with structural heart disease from two perspectives;...