Analysis Of Atrial Fibrillation Associated With High-sensitivity C-reactive Protein And Interleukin-18in Qinghai Region

Objective:By observing the levels of serum hs-CRP and IL-18changes in atrialfibrillation (AF) patients in the region of qinghai, to study relationship betweeninflammation and atrial fibrillation.Methods:A total of56patients with atrialfibrillation,23cases of patients with paroxysmal atrial fibrillation,33cases patientswith persistent atrial fibrillation.24cases is healthy controls (that is,the sinusrhythm group).All entrants in hospital early the next morning on an empty stomachblood5ml,3500r/min at room temperature under centrifugal5min, take the upperserum2ml,-80℃saved for later use.Immune turbidimetric method is used todetermine the hs-CRP, using ABC-double antibody sandwich ELISA method todetermine IL-18.Results:1、Atrial fibrillation group of hs-levels of hypersensitivec-reactive protein and interleukin-18was obviously higher than that of control grouppatients,Comparing the two groups was statistically significant difference (P <0.05).2、Compared with array by onset atrial fibrillation group, persistent atrialfibrillation group serum hypersensitive c-reactive protein (hypersensitive-CRP)andinterleukin-18(IL-18) levels increased significantly, the more similar between thetwo groups was statistically significant (P <0.05).Conclusion:Serum IL-18inpatients with atrial fibrillation and hs-CRP levels increased compared with the controlgroup, patients with persistent AF and IL-18and hs-CRP levels than patients withparoxysmal atrial fibrillation increased serum, suggesting that atrial fibrillation andinflammation closely related to atrial fibrillation may occur in inflammatorycytokines, play an important role in the development of the longer duration of AF, themore intense inflammatory response. Meanwhile, atrial fibrillation may exacerbatethe inflammatory response, the two complement each other in the development ofdisease.