The Risk Factors Associate With Brain Lesions In Cerebral Venous Sinus Thrombosis Analysis And Literature Review

Purpose: Discussion of intracranial venous sinus thrombosis secondary toparenchymal damage (including venous infarction or hemorrhage, cerebral edema,etc.) may exist associated risk factors (such as the extent and location of thrombosisin the venous sinuses, age, sex, onset to treatment time, the cause).Comparingdifferences of clinical symptoms and prognosis between two groups.Methods: Retrospective review of patients with CVST treated in The First AffiliatedHospital of Fujian Medical University between December2009to January2014.Confirmed by brain MRI or CT scans, the patients were divided into two groups.The patients of Group A without evidence of parenchymal lesions，and the patients ofGroup B with parenchymal lesions. The patients’clinical information，laboratoryexamination and imaging date were collected. A CVST scoring system was designedto quantify the overall distribution of the sinus clot.At the same time,we correlationanalysis “age, sex, and acquired or congenital thrombophilia,time of onset totreatment” whether these factors influence the likelihood of presenting with brainparenchymal lesions or not.Results: Fifty-four patients were included in the study, There were27patientswithout evidence of parenchymal lesions (group A) and27patients with parenchymallesions (group B). The mean CVST score was2.51in group A and4.33in groupB(P<0.05).The onset time of group A is166.07±382.32days, the finding reachedstatistical significance. and the onset time of group B is8.44±7.35days, the findingreached statistical significance. Age, sex, and acquired or congenital thrombophiliadid not influence the likelihood of presenting with parenchymal lesions.Conclusions: Among CVST patients，extensive venous sinus thrombosis, acuteonset are more likely to happen brain parenchymal damage. The group B also focuson severe clinical symptoms.