The Effect Of Rosuvastatin On Ventricular Arrhythmias In Elderly Patients Suffered From Acute Myocardial Infarction

Objective1、The aim of this study was to evaluate the effect of rosuvastatin with different doses on ventricular arrhythmias (frequent ventricular premature and non-sustained ventricular tachycardia) in older patients with acute myocardial infarction.2、It was to observe the relation between mortality and rosuvastatin with different doses in the period of3-month follow-up.3、To investigate the safety of rosuvastatin in the elderly.Methods Some130older patients with acute myocardial infarction were randomly divided into three groups:Groups A (with5mg/day rosuvastatin therapy, n=43), Groups B (given1Omg/day rosuvastatin therapy, n=45),Groups C (received20mg/day rosuvastatin therapy, n=42). The frequency of ventricular premature beat (VPB) and non-sustained ventricular tachycardia (NSVT) was recorded via Holter monitoring after hospitalization (24h and72h) and the results were compared.Results1、Ventricular premature beats decreased significantly in the Groups C than the others.(24h, p<0.01;72h, p<0.01). Meanwhile, a significantly reduction in NSVT was seen in the Groups C (24h, p<0.01;72h, p<0.01). But between Groups A and Groups B had no significant differences in reducing ventricular arrhythmias (P>0.01).2、When compared to patients without recorded NSVT, thirty two patients with NSVT share the following characteristics:having myocardial infarction in the past, diabetes mellitus, women, atrial fibrillation, an left ventricular ejection fraction(LVEF)<40%, left ventricular dimension in diastolic(LVDd)>55mm and few prior statin therapy. There were no side effects observed in all groups during the hospitality and follow-up.Conclusions Early20mg/d rosuvastatin treatment not only can obviously decrease VPB and NSVT but also has good security in elderly patients suffered from acute myocardial infarction.