Study Of NSE And S100B Concentration In Subretinal Fluid Of Rhegmatogenous Retinal Detachment

Objective To determine the concentration of Neuron-Specific Enolase (NSE) and S100B in subretinal fluid (SRF) and to assess the neural injuries in rhegmatogenous retinal detachment (RRD)Methods SRF specimen and blood serum were collected during the surgery in ninety-two cases with rhegmatogenous retinal detachment served as experimental group. Nineteen vitreous collected during cornea procurement from deceased patients and twenty normal serum served as control group. These specimens were detected using enzyme-linked immunosorbent assy (ELISA)。Results1.NSE and S100B centration’s difference of these patients who have rhegmatogenous retinal detachment, between in the subretinal fluid and the serum, was statistically significant(P>0.05).2. The experimental group was divided lweek,1-2weeks,2-4weeks,>4weeks on the basis of retinal detachment duration, the difference of NSE and S100B concentration in these groups were statistically significant (P<0.05)。3.The experimental group was divided<1quadrant,l-2quadrant,2-3quadrant,3-4quadrant on the basis of retinal detachment range, the difference of NSE and SIOOB concentration in these groups were statistically significant (P<0.05)。Conclusion Neuron and gliacyte injuries exist in the subretinal fluid of rhegmatogenous retinal detachment。These injuries enhance with retinal detachment range and duration,specially within two weeks; This topic is helpful for the selection of the treatment protocols and occasions of rhegmatogenous retinal detachment。...