Serum25-（OH）VitD₃, Betatrophin Levels And The Influencing Factors In Different Glycometabolism States

Objective： Serum25-(OH)VitD3deficiency is common, serumbetatrophin level is unclear, and serum25-(OH)VitD3, betatrophin levels maybe related to diabetes. We will observe serum25-(OH)VitD3and betatrophinlevels in different glycometabolism states, and investigate the relationshipbetween serum25-(OH)VitD3, betatrophin and clinical of indicators indifferent glycometabolism states.Methods：A total of460permanent residents of Fengxian aged40-60years were enrolled. Questionnaire, physical examination, biochemical, serum25-(OH)VitD3, serum betatrophin, body fat composition and bone mineraldensity were measured. Glucolipid metabolism, islet function, body fatcomposition and bone mineral density were observed in different glucosetolerance and also in people with25-(OH)VitD3deficiency and without25-(OH)VitD3deficiency. Pearson correlation coefficients were applied inanalyzing the correlations between serum25-(OH)VitD3, betatrophin andvarious indicators. Independent risk factors of25-(OH)VitD3deficiency wereanalyzed by Logistic regression.Results：There were63newly diagnosed patients with type2diabetes,108patients with pre-diabetes and289subjects with normal glucose tolerance.Serum25-(OH)VitD3had no significant difference in patients with newlydiagnosed type2diabetes and normal glucose tolerance. There were obviousdifferences in the distribution of body fat, but glucose, lipid, HOMA-IR,HOMA-β and bone mineral density had no significant differences between the group of25-(OH)VitD3deficiency and the group of without25-(OH)VitD3deficiency. Compared with impaired glucose tolerance and normal glucosetolerance, serum betatrophin levels were increased and the HOMA-βwasdecreased significantly in newly diagnosed type2diabetes patients. ByPearson correlation analysis，we found that serum25-(OH)VitD3level wasrelated to the percentage of body fat, lean body mass, muscle content, rightupper limb muscle content, trunk muscle content, lower limbs muscle content(P＜0.05) and had no relation to HOMA-IR, HOMA-β, glucose and lipid.Serum betatrophin was related to lean body mass, muscle content, right upperlimb muscle content, trunk muscle content, lower limbs muscle content in thepatients with newly diagnosed type2diabetes (P＜0.05) and was related toHOMA-IR and HOMA-β in normal glucose tolerance group and all subjects.Logistic regression analysis showed that the percentage of body fat, trunkmuscles content were independent factors to predict serum25-(OH)VitD3levels.Conclusion：Compared with normal glucose tolerance, serum25-(OH)D was lower in newly diagnosed type2diabetes. Serum25-(OH)VitD3had nosignificant difference with glucose, lipid, HOMA-IR, HOMA-βand bonemineral density. The percentage of body fat and muscle content affect theserum25-(OH)VitD3level. Serum betatrophin levels were increased andHOMA-βwas decreased significantly in newly diagnosed type2diabetespatients. Muscle content could affect the serum betatrophin levels, and serumbetatrophin may relate to islet β cell function.