| ObjectiveChronic rhinosinusitis is inflammatory diseases of nasal cavity and sinus, the occurrence of which is considered to relate to cilia-cleaning transport function, sinus patency of the anatomical structure, health condition of nasal cabity, systemic anti-infection ability, it’s a common disease, frequently occurring in the Department of ENT, and seriously affecting the patient’s daily life and health. In recent years, a large number of domestic and foreign epidemiological data shows, the incidence of chronic rhinosinusitis disease increased. Foreign scholars have formulated a series of guidance documents about chronic rhinosinusitis. In our country, Rhinologic Society has made several formulation, modification on diagnosis standards of chronic rhinosinusitis, but the relevant epidemiological data less. The main purpose of this epidemiological study is to get the prevalence of chronic sinusitis among residents in Changchun, and to analyze its relationship with life style, occupation exposure, environmen-tal factors and other related diseases, eventually to provide scientific basis for effective prevention of chronic sinusitis.Methods With randomly collecting1500residens from8community in Changhun, an epidemiological survey about CRS was made using stratified multi-stage cluster sampling method. The questionnaire was made according to Galen sinusitis cohort study.the main contents include:general situation, environ-mental factors and related disease investigation in three parts. The investigation is completed in the period from2012August to2012October. Diagnosis refer to Chronic nasal sinusitis diagnosis and treatment guidelines(2008, Nanchang). Detailed inquiry medical history and the essential medical examination were carried out if necessary. Through analysing the data collected from confirmed cases, we want to obtain the prevalence rate of chronic rhinosinusitis in Changchun, and its relationship with smoking, drinking, occupation, toxic gas exposure, allergic rhinitis, asthma and other diseases.Results1Using a screening questionnaire, we found148patients with chronic sinusitis from1500qualified survey, and the overall prevalence of CRS was9.87%; There was no difference about incidence between male and female;The incidence rate of chronic sinusitis in60~70years old group,50~60years old group,40~50years old group was highest respectively14.6%,12.6%,10.3%. There was no patient with chronic sinusitis found in0~10age group either80^90. Statistical analysis showed that the prevalence of sinusitis in different age groups had significant difference (x2=9.960, P<0.05);The incidence rate of CRS in Han and other ethnic group people was9.3%,16.2%, Ethnic minority has higher incidence, by x2test, those differences was significant (x2=5.785, P<0.05); The average family residential number of148patient with CRS (3.62±0.626) was more than that of1352non-sinusitis people (3.12±0.657), by T test, its showed that the difference was statistically significant (T=3.564, P<0.05). And the number of bedrooms and living area showed no significant difference on of sinusitis incidence (P>0.05);The incidence of chronic sinusitis among medical services staff was6.76%(10/148), which is more than that in the non-medical service staff (2.51%), there was a statistically significant difference (χ2=7.006, P<0.05);Compared with non-cleaning service staff, cleaning service staff had higher incidence of chronic sinusitis7.97%(10/148), the difference was a statistically significant (χ2=13.584, P<0.05); The incidence of CRS among different education level group showed "U" distribution, postgraduate degree and illiterate people were more likely to have CRS, comparing with other people, statistical analysis showed the significant difference (χ2=13.584, P<0.05);No statistically significant effects of marriage, BMI capita income was found(P>0.05)2By x2test, the difference of the incidence of CRS between smoking and non-smoking population was significant (χ2=15.016, P=0.028),11.6%smokers has CRS, while the incidence of non-smoking population was9.24%;People who had alcohol drinking habit showed higher rate of CRS than that of population who never drunk, the statistic analysis showed significant differences (χ2=6.699, P<0.05);While the crowd who often did bady exercise had lower prevalence rate of CRS, the incidence rate of chronic sinusitis in different physical exercise frequency group was significant difference (χ2=11.139, P<0.05);Among148CRS patients,25persons kept pets, while just121cases keeping pets in1352people without CRS, statistical analysis showed significant difference (P<0.05); The CRS group had higher rate of palcing carpet in theire family, compared with control group,there was statistically significant difference (P<0.05);The rate of workplace hazardous gas and chemical exposure in case group was higher than the control group, and the difference was significant (P<0.05);The similar outcomes were found among population who often exposed to humid moldy indoor environment and air conditioning environment;3The ratio of nasal congestion, purulent nasal secretions, olfactory dysfunction, pain in the head among patients with chronic sinusitis were respectively63.5%(94/148),48.6%(74/148),52.7%(78/148),48.6%(72/148);The rate of nasal-spray use, anti-inflammatory drug use, medical treatment, operation were33.1%(49/148),43.2%(64/148),4.3%(7/148), respectively;and the frequentcy and numbers of missing day from work or school for people with CRS were higer than the control group (P<0.05);Investigation showed that correlation between allergic rhinitis and sinusitis existed, allergic rhinitis patients were more likely to have CRS (χ2=75.287, P=0.000);The average age of onset of asthma was29.18±13.24years old; The morbidity rate of asthma in the crowd with CRS was26.3%(39/148), while the corresponding rate among non-chronic sinusitis people was5.1%(70/1352), showing significant differences (χ2=19.327, P<0.05);Incidence rate of Patients with chronic sinusitis and chronic obstructive pulmonary disease was16.2%(24/148), the rate of non-chronic sinusitis in patients with chronic obstructive pulmonary disease was6.3%(85/1352), difference was significant by statistical analysis(χ2＝22.560, P<0.05); Patients with CRS had more frequent stomach acid reflux symptoms than other people,χ2test showed statistically significant difference existed between two groups (χ2=30.044, P<0.05);in addition, aspirin exacerbated respiratory disease patients (AERD)had higher incidence of chronic sinus inflammation, showing a statistically significant difference(P<0.05).Conclusion1The rate of chronic sinusitis in Changchun was9.87%; gender, age, bady mass index, marital status had no significant effect on the incidence of sinusitis;family number, manual workers, health care and cleaning wokers, education-level related to higher incidence of chronic sinusitis. 2smoking, alcohol, pet, carpets, dust, chemical substances, humid moldy indoor environment, air conditioning related to the occurrence of chronic sinusitis.smoking population had higher incidence of CRS, comparing with non-smokers;alcohol, pets, frequency of air conditioning using, carpet, dust, toxic gas exposure, humid moldy indoor environment have close ralationship with CRS (P<0.05).3allergic rhinitis, asthma, chronic obstructive pulmonary disease, gastroesophageal reflux, aspirin exacerbated respir-atory disease have higher correlation with chronic sinust-is. |
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