The Relationship Between ADP-induced Platelet Aggregation And Early Neurological Deterioration And Prognosis In Patients With Acute Non-cardiac Cerebral Infarcts

Objective Aspirin is the most common anti-platelet drugs,which widely used intreatment of acute cerebrovascular events.However,even in strict accordance with acuteischemic stroke treatment guidelines,there are still a large part of the patient worsenedstandard aspirin therapy in patients with acute non-cardiac infarction.This article wasaimed to study the relationships between ADP-induced platelet aggregation and earlyneurological deterioration as well as early prognosis in patients with acute non-cardiacinfarction were investigated,in order to predict early neurological deterioration.Methods215acute non-cardiac cerebral infarct patients were admitted within72hoursafter onset and were consecutively recruited as a patient group.73cases were selected asa control group,who suffered benign positional vertigo,facial paralysis patients and wereadmitted to hospital at the same period.All the demographic and clinical data wererecorded.According to the NIHSS score assessed on the admitting day and the seventhday,the patients were classified into two groups:Deteriorated group and nondeterioratedgroup.The NIHSS in the former group increased≥2,and in the later group increased<2(stable)or decreased≥2(improve).Modified Rankin Scale (MRS) was assessed onfourteenth day.MRS≥2were classified as good prognosis group and MRS<2wereclassified as poor prognosis group.Retrospective analysis and SPSS17.0statisticalsoftware were adopted.t tests and chi-square test were used to compare the demographic and clinical data.Logistic regression was used to analyze the possible risk factors forearly neurological deterioration.Significant test standard was set at α=0.05(two-tailed).Results (1)There are differences in gender, hypertension,diabetes,LDL levels betweenpatient group and the control group(p<0.05),with statistical significance;(2)Among55patients in deteriorating group,there were35patients with PAGT≥0.7,accouting for63.64%,20patients with PAGT<0.7,accouting for36.36%;among160patients innondeteriorating group,there were70patients with PAGT≥0.7,accouting for43.75%,90patients with PAGT<0.7,accouting for41.86%;and there were differences with sex,hypertension,LDL,glycosylated hemoglobin,PAGT,non-plus have the responsibility ofstenosis,AT between aggravate group and non-aggravate group,with statisticalsignificance (p<0.05);(3)based on logistic regression exacerbations multifactorialanalysis showed that there are correlation with diabetes history,LDL,glycatedhemoglobin,PAGT,vascular stenosis in acute non-cardiac infarction and prognosis ofearly exacerbations,with statistical significance (p<0.05).The relevance between PAGTand early analysis of prognostic with acute exacerbations of non-cardiac infarction isindependent（OR=34.364,95%CI:4.422～267.029,P=0.001;(4)among105patients withPAGT≥0.7group,35patients with early poor prognosis,accouting for16.28%,70patients with good prognosis,accouting for32.56%.among110patients with PAGT<0.7group,20patients with poor prognosis, accouting for9.30%,90patients with goodprognosis,accouting for41.86%.There was significant differences between two groupsin early prognosis (p<0.05).Conclusions1、ADP-induced PAGT was related with early neurological deteriorationand prognosis in patients with acute non-cardiac cerebral infarcts.2、Diabetes history,LDL,glycated hemoglobin,vascular stenosis was alsoassociated with early disease aggravation and prognosis in acute non-cardiac infarction.