Clinical Efficacy And Safety Of Antithrombotic Combined With Anti-inflammatory Therapy In Patients With Acute Cerebral Infarction

Objective: Objective to explore the clinical efficacy and safety of antithrombotic therapy combined with low-dose dexamethasone in the treatment of acute cerebral infarction.Methods: 40 patients with acute cerebral infarction in 24 hours were randomly divided into small dexamethasone group,small dose group,microdexamethasone group and control group.In conventional antithrombotic and statin therapy(control group)were combined with dexamethasone on the basis of 1.25 mg,2.5 mg and 5 mg(followed by trace dexamethasone group,the small amount of dexamethasone group,small group dexamethasone)intravenous drip,once a day,a total of 7 d.Between groups in treatment 1 day and 7 days after the blood routine and blood sedimentation,in the first month and 3 months after treatment the Barthel index and Rankin scale to all of the nervous system function in patients with cerebral infarction.Results: a small group of blood sedimentation,trace group and control group in the small dose group slowed significantly,and there are significant difference(P<0.05),and small dose group and the trace group and the control group no significant difference.According to Barthel index and the modified Rankin scale evaluation as a result,a small group of nervous function,trace group and control group in the small dose group improved significantly,and there are significant difference(P<0.05),and small dose group and the trace group and the control group no significant difference.Blood routine and blood biochemical examination showed no obvious difference.Conclusions:1.On the basis of routine antithrombotic and statin treatment,small dose dexamethasone can significantly improve patients’ neurological deficits and improve their long-term viability.2.Relatively safe in clinical application,no obvious side effects were found,and with the increase of patients’ application days,the advantage of dexamethasone was more obvious.3.Small dose dexamethasone is a safe and effective therapeutic drug,and the long-term benefit is worthy of our application in the clinical work of treating cerebral infarction.