Expression And Clinical Significance Of TAZ And KLF5in Urinary Bladder Carcinoma

Objective:Urinary bladder carcinoma ranks first in the rates of morbidity and mortality related to tumors in the urinary system, and is characterized by difficulty in detection, susceptibility to relapse and poor prognosis. The occurance of bladder cancer is a multifactorial, complex multi-stage interactive process, whose pathogenesis mechanism is not clear so far, thus leading to the lack of effective diagnosis, prevention and treatment measures. KLF5is a recently discovered zinc finger protein transcription factors which regualte gene expression through inhibition or activation of target gene transcription, therefore has played an important role in cell proliferation, differentiation, apoptosis and tumor progression. TAZ is a transcriptional coactivator that can promote cancer cell proliferation and tumorigenesis through the interaction with a variety of regulatory factors, KLF5and TAZ transcription factors may interact with each other with the WW domains to promote cancer proliferation and tumor formation. In this study, by detecting the expression of KLF5and TAZ in bladder cancer and normal bladder tissue, we analyzed the correlation of a number of clinicopathological parameters including degree of differentiation, level of pathology and TNM staging as well as the corelation between these two factors.Methods:Immunohistochemistry was used to detect the expression level of KLF5and TAZ in46cases of bladder cancer and10cases of normal bladder tissue, the results were use for further analysis of correlation of a number of clinicopathological parameters including degree of differentiation, level of pathology and TNM staging as well as the correlation between these two factors.Results:positive expression of KLF5and TAZ in bladder carcinoma are higher than normal bladder tissues, the positive expression rate of KLF5in bladder cancer tissues of78.3%(36/46), TAZ expression was76.1%(35/46), showing a significant difference (P<0.05) compared with KLF5and TAZ expression levels in normal bladder tissue. KLF5and TAZ protein expression are significantly associated with tumor differentiation (P=0.023; P=0.008) and TNM stage (P=0.025; P=0.016), but showed no significant correlation with sex, pathological stage and tumor metastasis.Conclusion:The up-regulation of TAZ and KLF5expression is closely related to tumor growth, differentiation, invasion and prognosis, indicating that TAZ and KLF5are important markers for bladder cancer development and prognosis of patients with pros and cons, and have the potential to become a diagnostic indicators, therefore provide important theoretical basis for further clinical studies.