Comparison Between Methylene Blue And Carbon Nanoparticles On The Sentinel Lymph Node Biopsy In Cervical Cancer Laparoscopic Surgery

Objective:To evaluate the feasibility of intraoperative detection of sentinel lymph nodes (SLN) in patients with cervical cancer.Methods:Forty-six patients with clinical stage Ⅰb～Ⅱa cervical cancer treated with laparoscopic surgery were enrolled in the study. The patients were divided into two groups. In group one, Methylene blue dye was injected into the peritumoral tissues of cervix before the time of laparoscopic hysterectomy and bilateral pelvic lymphadenectomy. In group two, carbon nanoparticles suspension was injected into the peritumoral tissues of cervix before the time of same procedure. Dyed nodes identified as SLNs were excised.Result:The SLNs were identified in39cases. In the blue dye group, the SLNs were identified in20cases, the SLNS were successfully detected in87%(20/23); A total of52SLNs with a mean number of2.7SLNs (range,1-7).Seven patients had nodal metastases and the accuracy was100%(20/20), fake negative rate was0. Carbon nanoparticles group, the SLNs were identified in19cases, the SLNS were successfully detected in82.6%(19/23); A total of49SLNs with a mean number of2.5SLNs (range,1-6).Six patient had nodal metastases and the accuracy was100%(19/19), fake negative rate was O.No adverse reactions or injuries were attributed to the study. There was no significant difference between the two groups (P>0.05).Conclusion:Intraoperative SLN identification with methylene blue dye or carbon nanoparticles in cervical cancer is feasible and safe.