Effects Of Taurine On The Mossy Fiber Sprouting In The Hippocampus Of Epileptic Rats Induced By Pilocarpine

Objective:To study the effects of taurine on the hippocampal mossy fibers sprouting in rat model of epilepsy induced by pilocarpine.Methods:1. Wistar rats will be injected with pilocarpine to establish the model of epilepsy, and then the rats are divided into three groups:the blank group, taurine group and control group (n=10,10,10).2. In taurine group, the rats were injected intraperitoneally with taurine at the dose of2g/kg daily for a total of6days; the effects of taurine will be determined by evaluating the ethological changes of seizure and comparing both duration and grade score of seizure.3. After the ethological study, we will examine the mossy fiber sprouting in the hippocampus of pilocarpine-induced epilepsy rats.Results:1. Both the duration of seizure and seizure grade in taurine group were significantly reduced than those in the blank group and the control group.2. The scores of mossy fiber sprouting in taurine group were also reduced than those in blank group and the control group.Coneluosion:The taurine can reduce both the duration and grade of seizure; and the hippocampal mossy fibers sprouting was also affected by the treatment of taurine.