| Objective： Kawasaki disease is common in children with febrile illness ofunknown etiology, mainly involving the cardiovascular system, in recent years, hasbecome the leading cause of acquired heart disease. Understanding the incidence andepidemiological characteristics of Kawasaki disease, etiology, pathogenesis, etc., to helpguide diagnosis and treatment of Kawasaki disease. Due to the lack of specificlaboratory diagnosis of KD indicators and the gold standard, KD is mainly a clinicaldiagnosis, which incomplete Kawasaki disease in the larger higher incidence of smallbabies, early diagnosis is difficult, complicated by the possibility of coronary arterylesions, by the people attention. With the development of auxiliary examinationtechniques, some of the more meaningful the early diagnosis of KD specific marker wasfound for qualitative coronary artery lesions, diagnosis meaningful new imagingtechniques are carried out applications.Because the cause of Kawasaki disease is not yet known,and therefore itsdiagnosis,treatment and prognosis are affected.The paper combined KD Mycoplasmapneumoniae infection in children with coronary artery lesions related research.Methods: Retrospective analysis of clinical data in January2004to December2013Fever income pediatric hospital, finally diagnosed as KD79cases of children.And a random sample of150cases over the same period of infectious diseases withfever in hospitalized children.1.According to whether the KD is divided into KD groupand non KD group,compare the MP infection rate between the two groups;2.Accordingto MP infection in children with KD are merged into MP MP infection group and non- infected group, two groups of peripheral blood C-reactive protein (CRP), white bloodcell count (WBC), neutrophil count (N), platelet count (PLT), erythrocyte sedimentationrate (ESR), creatine kinase isoenzyme heart (CK-MB), glutamic acid aminotransferase(ALT), coronary abnormality rate comparison and analysis, and statistical treatment ofthe two groups of and outcome;3.According to whether the occurrence of coronarydilatation (CAD) into CAD group and non-CAD group, two groups of MPinfection.;4.In the KD group, depending on the degree of consolidation CAD coronarydilatation of coronary artery divided into groups, small groups and giant coronary arteryaneurysm aneurysm group compared three groups of MP infection rates;5.According tothe merger of MP infection in children with KD whether anti-MP line therapy,anti-MP isdivided into a treatment group and the treatment group were not anti-MP fevercompared between the two groups and hospitalization time.The next morning afteradmission venous blood collected8ml,MP same period detection antibody titers andrelated laboratory tests,review again after discharge.Admission and1to3months afterunderwent heart-color checks.Using SPSS19.0statistical software analysis software forclinical data processing,P<0.05was considered statistically significant.Results:1.79cases in27cases of children with KD MP positive,MP infection ratewas34.17%(27/79);random sample of150cases of non-KD-positive children in24cases of MP,MP infextion rate was16%(24/150)KD group of MP infection thannon-KD group,a statistically significant difference(P<0.05).2.In79cases of KD,the peripheral MP infection in children27casesCRP,ESR,CK-MB.ALT levels higer than the non-MP52cases of infection inchildren,there is a statistically significant difference(P<0.05);But WBC,N,PLT level,nostatistically significant difference(P>0.05).3. In79cases in27cases of KD MP infection in children in cases of merger CAD26,CAD incidence was96.30%(26/27),52cases of infection in children with non-MPmerge CAD34example,CAD incidence was65.38%(34/52);MP infection MP CADwas higer than the non-infected group,there is a statiscally significant difference(P<0.05).4.In79cases of children with KD in60children cases with CAD positive in25cases of MP,MP infection rate was41.67%(25/60),patients without CAD in two cases of19cases of positive MP,MP infection rate was10.53%(2/19),CAD group of MPinfection than non-CAD group, there is a statiscally significant difference(P<0.05).5.In KD merge CAD60infants,50cases of childrem with coronary dilatation in23cases of MP positive MP-positive rate was46%(23/50);7cases of children withcoronary aneurysms3cases of small and medium-positive MP,MP-positive rate was42.86%(3/7);children in3cases of giant coronary aneurysms1case ofMP-positive,MP-positive rate was33.33%(1/3),there was no statistically significantdifference(P>0.05).6. KD merger of MP infection in27infants,15cases of anti-MP treatment,theaverage duration of fec=ver in childrenr(9.1±5.3)d, the average length ofstay(7.2±3.3)d;12patients without anti-MP treatment, the average duration offever(11.8±6.1)d,the average length of stay(9.8±5.4)d,anti-MP treatment group than inthe treatment group is not anti-MP fever and hospital stay were shorter,there is astatistically significant difference(P<0.05).7.35cases of children with KD review after pre-treatmentCRP,WBC,N,PLT,CK-MB,ALT levels decreased over the treatment difference wasstatistically significant(P<0.05).ESR levels before and after treatment showed nosignificant difference(P>0.05).8.Children with KD1-3months after cardiac ultrasound again,the follow up to the30cases of non-MP infection,24cases of coronary artery to restore normal coronaryrecovery rate of80%;follow-up to the25cases of KD patients infected with MPchildren returned to normal in20cases of coronary coronary recovery ate of80%, therewas no statistically significant difference between two coronary recovery rate(P>0.05).Conclusions:1. MP infection rate in children with KD,MP may be one of the causes of KD.2.MP’s combined high inflammatory markers in children with KD,coronary artery damage and more,MP can aggravate immune injury,release put more inflammatorycytokines,leading to the formation of CAD.3.CK-MB,ALT,such as children with hign levels of clinical infection should beconsidered possible merger MP,giving Aspirin and gamma globulin therapy to alleviateimmune injury,fever and shorter hospital stay. |
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