The Clinical Pathologic Significance Of CD151Expression In Breast Cancer

Objective:To study the expression of CD151mRNA and protein in breast cancer, and investigate the clinical pathological significance of CD151in breast cancer patients.Methods:From open reading TCGA website (http://tcga-data.nci.nih.gov) download normalized breast cancer CD151mRNA, and to detected CD151protein expression in breast cancer tissues by immunohistochemistry. And to analysed the relationship between CD151expression and clinical features by statistic methods.Results:CD151mRNA overexpression was found to be significantly associated with lymph node metastasis, ER, PR, and breast subtypes. In LuminalB type breast cancer, CD151mRNA overexpression was found to be significantly associated with lymph node metastasis, clinical stage and patients overall survival. However, in TNBC type, CD151mRNA overexpression was found to be significantly associated with poor overall survival. CD151protein was overexpressed in breast cancer tissues, and almost not expressed in normal mammary duct epithelium. In breast cancer tissues, CD151protein overexpression was found to be significantly associated with lymph node metastasis, ER, PR, HER2, and breast subtypes.Conclusion:The detection of CD151gene is important indicator for evaluate breast cancer metastasis potential and prognosis, especially in LuminalB and TNBC subtypes.