Correlation Analysis Of Visfatin With The Traditional Cardiovascular And Cerebrovascular Disease Risk Factors

Objective: Visfatin is a cytokines, which mainly secreted by visceral adipose tissue alsoexpressed in liver, spleen, bone marrow, muscle and other tissues and organs. It can bind toand activate the insulin receptor, lowering blood sugar and playing insulin-like role. Visfatinalso involved in the body’s metabolism of lipids, vascular endothelial dysfunction,vasculogenesis, atherosclerosis, ischemia-reperfusion injury and other pathophysiologicalprocess of cardiovascular diseases. This study attempts to analyze the relationship betweenvisfatin and traditional risk factors for cardiovascular disease and verify the consistency ofthem, in order to provide evidence for the study of risk factors and control and preventionmeasures for cardiovascular disease.Methods: During August to September in2010，our research group using the randomcluster sampling method to select17villages from49administrative villages in Ningyangcounty of Shandong province. Then select all permanent residents aged35to74years old inthese villages as our respondents and3,500people was covered. All the individuals shouldfinished questionnaire, physical measurements and blood biochemical indices test underfasting state. Spearman correlation and multiple linear regression analysis were applied toevaluate the correlations between plasma visfatin levels and traditional cardiovascular diseaserisk factors, which included systolic blood pressure, diastolic blood pressure, blood sugar,blood lipid, waist circumference, body mass index, smoking and alcohol consumption. Forfurther study, the differences of plasma visfatin content between normal population andhypertension, diabetes, dyslipidemia, metabolic syndrome patients were analyzed. In this way,we try to find out the relationship between visfatin and CVD.Results:(1) Visfatin levels were positively related to weight, waist-high ratio, WC, BMI,DBP, FPG, LDL-c, TG and CRP (r=0.221,0.271,0.310,0.327,0.075,0.184,0.042,0.178,0.069, P<0.05); but they were negatively correlated with age, alcohol consumption, HDL-c and pulse pressure (r=-0.131,-0.173,-0.184,-0.048, P<0.01); they had no significantcorrelation with TC, SBP and smoking consumption.(2) Multiple linear regression analysisshowed that BMI, FPG, TG and HDL-c was incorporated into the regression equation, andcan be seen as influence factors for the visfatin content;(3) Visfatin levels in diabetes,hypertension, dyslipidemia, overweight/obesity and metabolic syndrome patients aresignificantly higher than in normal population.Conclusions: Plasma visfatin levels are significantly correlated with the traditionalcardiovascular disease risk factors, visfatin content in patients with various chronic diseaseswere significantly higher than in the normal population. It suggested that visfatin has a closelyrelationship with the development of cardiovascular disease and may become a new target forprevention and treatment of cardiovascular disease. But the exact mechanism of visfatin acton CVD diseases is not distinct, there still need large population cohort studies to ensure thecorrelationship between them.