| BackgroundThyroid cancer is one of the common clinical endocrine malignancies. In recent years, the incidence rate showed an increasing trend, has now risen to common malignancy in Asia Pacific and North America. All human malignancies, thyroid cancer accounts for about0.8%to about1%. In recent years, about thyroid cancer etiology and pathogenesis of more and more was discovered and cognition, but at the molecular level, its pathogenesis has been unable to clear. SOX (SRY related high mobility group box) gene family is a new family of genes encoding transcription factors found in animals, the product has an HMG motif conserved region involved in a variety of early embryonic development, and is known to be involved the development of a variety of human tumors. SOX4gene belongs to a family of SOX subfamily C, expressed in epidermal stem cells and glioma cells in the bottom of the hair follicle stem cells, on the type of stem cell differentiation stability played an important role. Therefore, in the strict and orderly development of cell differentiation process, SOX4gene mutation, deletion or over expression or addition can cause congenital abnormalities, but also closely related to tumor formation and development. At present, the SOX4develop relations with thyroid cancer rarely reported in the literature.ObjectiveResearch in papillary thyroid cancer, benign thyroid disease tissues, adjacent normal thyroid tissue nodules relative expression of SOX4analyze the relationship between the gene and thyroid cancer, and to explore the development of mechanisms at the genetic level of PTC.MethodCollect125wax blocks of thyroid tissue specimen from the First Affiliated Hospital of Zhengzhou University diagnosed by the pathologist between January2012to December2012, including69cases of thyroid cancer,30cases of nodular and26cases of normal thyroid tissue next to nodular. Using immunohistochemical methods to explore SOX4expression in different thyroid tissues, while application software package SPSS17.0statistical analysis the relevant data. ResultsIn the69cases of papillary thyroid carcinoma,51cases SOX4overexpressed,18cases reduced expression,in the30cases of nodular goiter tissue,17overexpressed and13reduced, in the26cases of normal thyroid tissue next to nodules; only5overexpressed and21decreased. Compared between three groups,χ2=17.275, p<0.05, SOX4gene expression differences were statistically significant. Compared with each other, PTC and nodules(p=0.009),PTC and normal tissue(p<0.001),nodules and normal tissue(p=0.112). To PTC, SOX4expression level is related with tumor size (χ2=5.699, P=0.017)and lymph node metastasis (χ2=4.6, P=0.032), but not with sex (χ2=0.548, P=0.459), and age (χ2=0.053, P=0.818). Conclusions1. SOX4gene is highly expressed in thyroid cancer cells, may be involved in the development of thyroid cancer. SOX4gene may be a cancer-promoting gene for PTC.2. SOX4gene may have a role in the diagnosis of PTC... |
PDF Full Text Request