The Application Of Hydrogen Proton Magnetic Resonance Spectrum In Infant Spasm

Infant spasm is a kind of intractable epilepsy syndrome, known to many factorscan lead to the occurrence of the disease, the disease pathogenesis is still unclear,clinical often characterized by recurrent seizures, poor prognosis. Because of thechildren with intractable epilepsy may cause intelligence, body damage, which in turnbrings a series of psychological and social problems, so early diagnosis andreasonable has important clinical significance. In epilepsy diagnosis, imagingtechnology has potential application value, with the rapid development of magneticresonance (NMR) technology in recent years, noninvasive from living expression ofepilepsy pathological changes in brain cell metabolism, functional magneticresonance imaging than conventional magnetic resonance technology has theadvantages, is widely applied in epilepsy diagnosis, hydrogen proton magneticresonance spectrum analysis (1H-MRS) is currently the only can noninvasivedetection of living tissue metabolism imaging technology, the functional imagingtechnology has gradually become a kind of the powerful tools for the study of cellneurobiology field. If no system of regular treatment, seizures gap has graduallyshorten the trend, as soon as possible and reasonable treatment, prevention, forimproving the prognosis of children with development for intractable epilepsy, toavoid or reduce the occurrence of a series of psychological, social and physicalbarriers have important clinical significance.1H-MRS in epilepsy diagnosis,monitoring a evolution and objectively reflect the biochemical metabolism in the brain as to provide theoretical basis for clinical. Therefore, this study proposed byhydrogen proton magnetic resonance spectrum analysis technology to explore thechange of brain function with infant spasm.ObjectiveTo discusse the change of the biochemical metabolism in the brain with infantspasm through hydrogen proton magnetic resonance spectrum （1H-MRS).Materials and MethodsThe hydrogen proton magnetic resonance spectrum analysis （1H-MRS）testresults of40infants with infant spasm were collected in neurology department whichwere admitted intoThe Third Clinical College of Zhengzhou University fromNovember2011to June2013,the hydrogen proton magnetic resonance spectrumanalysis test results were analyzed retrospectively, to select the same interested area:bilateral basal ganglia, thalamus, temporal lobe, obtain relative concentration andNAA/(NAA+Cr), Cho/Cr, NAA/Cr ratio, compared with10cases of the controlgroup infants spectrum data.(Which have no central neurol system’s diseases).ResultsRatios of NAA/Cho+Cr, Cho/Cr,and NAA/Cr in bilaterally basal ganglia,thalamus and temporal lobe’s VOI between the patients and controls（x s，%）：1. The patients Group:The right of basal ganglia：NAA（/Cho+Cr）：(0.64±0.10)，Cho/Cr：(1.56±0.35)，NAA/Cr：(1.38±0.13)；The left of basal ganglia：NAA/（Cho+Cr）：（0.60±0.11），Cho/Cr：（1.73±0.39），NAA/Cr：（1.46±0.23）； The right of thalamus：NAA/（Cho+Cr）：（0.67±0.18），Cho/Cr：（1.54±0.41），NAA/Cr：（1.40±0.16）；The left of thalamus: NAA/（Cho+Cr）：（0.66±0.16），Cho/Cr：（1.73±0.49）， NAA/Cr：（1.48±0.19）；The right of temporal lobe：NAA/（Cho+Cr）：（0.76±0.16），Cho/Cr：（1.54±0.31），NAA/Cr：（1.41±0.13）；The left of temporal lobe：NAA/（Cho+Cr）：（0.66±0.14），Cho/Cr：（1.68±0.58），NAA/Cr：（1.48±0.20）；2. The control group：The right of basal ganglia：NAA/（Cho+Cr）：(0.78±0.07)，Cho/Cr：(1.35±0.07)，NAA/Cr：(1.67±0.09)；The left of basal ganglia：NAA/（Cho+Cr）：(0.79±0.07)，Cho/Cr：(1.52±0.08)，NAA/Cr：(1.68±0.09)；The right of thalamus：NAA/（Cho+Cr）：(0.77±0.07)，Cho/Cr：(1.37±0.10)，NAA/Cr：(1.66±0.09)；The left of thalamus:NAA/（Cho+Cr）：（0.78±0.07），Cho/Cr：（1.41±0.12）， NAA/Cr：（1.62±0.09）；The right of temporal lobe：NAA/（Cho+Cr）：（0.85±0.14），Cho/Cr：（1.26±0.07），NAA/Cr：（1.74±0.09）；The left of temporal lobe：NAA/（Cho+Cr）：（0.88±0.14），Cho/Cr：（1.21±0.07），NAA/Cr：（1.41±0.07）；ConclusionsHydrogen proton magnetic resonance spectrum analysis can assess the change ofthe biochemical metabolism in the brain, The NAA/(Cho+Cr) and the NAA/Crratios drops in the respectively Volume of interest of brain with infant spasm (basalganglia, thalamus), Cho/Cr ratios increases, lesion area often visible tall lactatepeak.