Release 3.0 T Magnetic Resonance Phosphorus Spectroscopy Of The Quadriceps Energy Metabolism In Vivo

Objective To evaluate the energy metabolism of skeletal muscle in sprinters using 3.0 tesla Phosphorus Magnetic Resonance Spectroscopy(31P-MRS).Methods 31P-MRS was acquired from quadricep muscles in 14 trained sprinters 16 non-trained healthy volunteers, spectra were analyzed using matlab software. concentration of inorganic phosphate(Pi), phosphocreatine(PCr) and adenosine triphosphate(ATP) was measured from area under the peak. Concentration of adenosine diphosphate(ADP) and intracellular pH value was calculated from the biochemistry reaction equilibrium.Results Concentration of PCr and ATP in the muscle of trained sprinters were significantly higher than those in the volunteers, Sprinters had lower PH value than volunteers, no difference were observed in the concentration of ADP between two groups.Conclusion Trained athlete had higher content of ATP and PCr indicating a more efficient mitochondrial phosphorlation system. Objective To evaluate the skeletal muscle mitochondrial function using in vivo dynamic phosphorus magnetic resonance spectroscopy(31P-MRS) on clinical 3T MR system.Methods 31P-MRS was acquired from skeletal muscles in 26 healthy volunteers, spectra were analyzed using matlab software. concentration of inorganic phosphate(Pi), phosphocreatine(PCr) and adenosine triphosphate(ATP) of every state was measured from area under the peak separately. Concentration of adenosine diphosphate(ADP) and intracellular pH value was calculated from the biochemistry reaction equilibrium.Resluts During exercise, PCr concentration decreased, Pi, Pi/PCr and ADP values increased, in recovery state, Concentration of every phosphate compound come back to the resting state gradually.Conclusion 3.0 T high field intensity dynamic phosphorus magnetic resonance spectroscopy technique can reflect skeletal muscle mitochondrial function in vivo and provide valuable information to evaluate muscle functional imaging, Lay a foundation of researching muscles related diseases. Objective To evaluate the energy metabolism of skeletal muscle in type2 diabetes patients and healthy volunteers using 3.0 tesla Phosphorus Magnetic Resonance Spectroscopy(31P-MRS).Methods 31P-MRS was acquired from quadricep muscles in 18 type2 diabetes patients and 20 healthy volunteers, spectra were analyzed using matlab software. concentration of inorganic phosphate(Pi), phosphocreatine(PCr) and adenosine triphosphate(ATP) was measured from area under the peak. Concentration of adenosine diphosphate(ADP) and intracellular pH value was calculated from the biochemistry reaction equilibrium.Resluts Concentration of Pi,PCr andβ-ATP in the skeletal muscle of type2 diabetes patients were significantly lower than those in the volunteers, values of ADP and Pi/PCr value were higher in DM patients compared to those in the volunteers,PH value did not showdifference between two groups. After exercise, DM patients revealed lower PCr recovery rate than the control group.Conclusion Type2 diabetes patients showed impaired mitochondrial oxidative phosphorylation function, and showed a lower energy state than the control group.