Correlations Of Serum Vaspin Concentration With Blood Pressure And UACR In EH Patients

Objective:to investigate whether serum vaspin concentration was associated with the blood pressure and urine albumin to creatine ratio (UACR) in hypertensive patients.Methods:We measured fasting serum vaspin concentration in89subjects with essential hypertension (49subjects with normal urine albumin to creatine ratio;40subjects with increased urine albumin to creatine ratio)and49sex-matched healthy control subjects using the enzyme-linked immunosorbent assay, measured the urine albumin to creatine ratio in kidney disease laboratory in xiangya hospital.To explore the correlations of serum vaspin concentration with blood pressure and UACR.Result:1. serum vaspin concentration was significantly lower in hypertensive subjects compared with the control subjects(P<0.05), serum vaspin concentration was significantly lower in hypertensive subjects with UACR compared with the hypertensive subjects without UACR。2.Spearson correlation analysis revealed that serum vaspin concentration was negatively related to SBP、DBP、UACR (r=-0.398, P＜0.001; r=-0.507, P<0.001; r=-0.381, P<0.001), UACR was positively related to SBP、DBP、LDL-C、Hs-CRP (r=0.494,P＜0.001; r=0.631, P<0.001; r=0.193, P=0.027; r=0.329, P=0.001)。3.multiple stepwise regression analysis revealed that BMI、 fasting plasma glucose、vaspin、Hs-CRP were significantly and independently associated with SBP (β=1.788,8.6,-1.371,1.068; P=0.000,0.000,0.000,0.045). BMI、vaspin、fasting plasma glucose were significantly and independently associated with DBP (β=1.191,-1.46,4.285; P=0.000,0.000,0.006); DBP、vaspinwere significantly and independently associated with UACR(p=0.064,-0.063; P=0.000,0.009).Conclusion:1. Serum vaspin concentration is negatively related to SBP and DBP in essential hypertensive subjects.2.Serum vaspin concentration is negatively related to UACR in essential hypertensive subjects3. Serum vaspin concentration may be a assess index of blood pressure and a predictor of UACR in essential hypertension.