Correlation Of Serum Vaspin Concentration In Patients With Acute Cerebral Infarction

Objective: This study was intended to investigate the relation between visceral adipose tissue sources of serine protease inhibitors(Vaspin) and acute cerebral infarction, the association of Vaspin with the severity of internal carotid and intracranial artery stenosis, and the value to assess the prognosis of cerebral infarction.Methods: This study collected 50 patients in the first 48 h of cerebral infarction that consecutively admitted the Neurology Department of the Second Affiliated Hospital of Chongqing Medical University as cerebral infarction group. There are 50 cases of healthy physical examination persons in the same period as the control group. To collect the general clinical and biochemical characteristics of two group, such as fasting plasma glucose, insulin, TG, TC, HDL, LDL, SBP, DBP,hsCRP, and the vascular examination, such as double carotid chromatic ultrasonic and intracranial artery examinations including the MRA、CTA and/or DSA. The serum Vaspin concentrations were measured by using enzyme-linked immunosorbent(ELISA). In course of 3 months end point events of observation time, evaluation of patients with nerve function and ability of life. NIHSS、Modified Rankin and Barthel scales evaluated the patients’ nerve function and ability of living at onset and at month 3.Results: No statistically significant difference was found between 2 groups in the genral clinical characteristics. Vaspin levels were found to be significantly lower in the patient group compared with the control group, while the blood pressure and hsCRP were found to be higher. However, no relation was established between Vaspin levels and the severity of internal carotid and intracranial artery stenosis. No relation between Vaspin levels and the plaque feature of internal carotid artery. We do not found Vaspin is the independent risk factors for cerebral infarction and does not show the value of prognosis prediction. Vaspin in serum concentration has certain diagnostic value for cerebral infarction.Conclusions: Vaspin levels have been shown to significantly decrease in acute cerebral infarction patients, which has certain value to the diagnosis. The serum Vaspin levels may associate with the plaque feature, but it was not found the relation between Vaspin levels and the severity of the internal carotid and intracranial artery stenosis in this study.