The Effects Of Low Dose Aspirin On Hemorheology And Catheter Dysfunctionsrelated To Fibrin Sheathsof The Cancer Patients With PICC

Objective:To explore the effects of low dose aspirin on hemorheology and catheter dysfunctions related to fibrin sheaths of the cancer patients with PICC.Methods:This study was an experimental study. It was conducted between May2013and January2014at Second Xiangya Hospital, Central South University in Changsha, China. Totally96cancer patients with Peripherally Inserted Central Catheter (PICC) were selected and randomly assigned to experimental (n=48) or control (n=48) group. Subjects in the experimental group received route PICC maintain technique and took aspirin100mg per day after dinner, while the control group received route PICC maintain technique only. The aspirin was taken at half an hour after dinner for four months. The prevalence of catheter dysfunction related to fibrin sheath and hemorheology indexes of the two groups were measured prior to study and at the end of the2nd and4th months, the drug safety indexes were monitored during the research. SPSS19.0was applied to establish the database, and repeated measures ANOVA was used to compare the effects of low dose aspirin on hemorheology indexes. In addition, generalized estimating equation was used to compare the effects on the incidence rate of catheter dysfunctions.Results:(1) Among the96patients taken in study, one patient died, six patients ended the treatment, one patient turned to the other department, and88patients completed the study.(2) Repeated measures ANOVA revealed that whole blood low sheathed viscosity and red blood cell aggregation index had significant time effect as well as interaction effect, whole blood high sheathed viscosity and red blood cell deformability index had significant intervention main effect and plasma viscosity had significant intervention effect as well as time effect (P<0.05).(3) Repeated measures ANOVA revealed that infusion speed had significant interaction effect, time effect as well as intervention effect(P<0.01). Generalized estimating equations indicated that the prevalence of mechanical valve and plugging between the two groups had significant differences (P<0.05), while the occurrence of thrombus and infection had no statistical differences.Conclusion:(1) Oral low dose aspirin could improve hemorheology, lower red blood cell aggregation ability, enhance erythrocyte deformation ability, and decrease the whole blood viscosity and plasma viscosity to some extent.(2) Oral low dose aspirin could lower the prevalence of catheter dysfunctions related to fibrin sheaths in the cancer patients with PICC, increase the infusion speed and decrease the prevalence of mechanical valve and plugging. However, whether it could reduce the incidence of thrombosis and infection related to PICC haven’t been confirmed.