Sensitivity Analysis Of Confocal Microscopy And Corneal Scraping For Fungal Keratitis

Objective To analyze confocal microscopy and corneal scrapingdiagnostic rate of fungal keratitis.Methods The Cochrane Library, Medline, Embase, ChineseBiomedical Literature Database (CBM), Chinese Scientific JournalsDatabase (VIP), Chinese Journal Full-text Database (CNKI), Wanfangdigital journals were searched.Studies about confocal microscopy andcorneal smear for inspecting fungal keratitis were included. Positive datasof confocal microscopy and corneal scrapings were statistical analysis withthe chi-square test.Results A total of12literatures were included, the total number ofclinical diagnosis of fungal keratitis cases was744eyes.Among them, thenumber of confocal microscopy observing hyphae or spores was in701eyes, corneal scraping finding out fungi was in464eyes. The confocalmicroscopy and the blade in the two groups respectively used chi squaretest for statistical analysis.If P>0.05, showed that the positive rate ofinclusion confocal microscopy literature no difference, and can be combined as a group.If P<0.05, showed the difference of the dates wasstatistically significant, and can not be combined. Diagnostic rate ofconfocal microscope was94.2%(701/744)that was significantly higherthan the diagnostic rate of the traditional corneal scraping test (30%-84%).Conclusion Confocal microscopy on fungal keratitis is a highdetection rate, non-invasive, rapid means of inspection and can be widelyused in clinical to improve and speed up the diagnosis of fungal keratitis.