Clinical Studies On The Fine Needle Aspiration Biopsy Processed By Cytologic Smear And Cell Block Techniques For The Diagnosis Of Lacrimal Gland Lesions

Objective:To study the value of fine needle aspiration biopsy (FNAB) in the diagnosis of space-occupying lesions (SOLs) of the lacrimal gland.Methods:From December2009to January2012,48cases diagnosed as SOLs of the lacrimal gland by the clinical symptoms and imaging examination in the Eye&ENT Hospital of Fudan University, who need surgery or biopsy for treatment, were selected for this study. All the specimens were performed fine needle aspiration cytology and CB method with immunostaining. The remaining was conducted the conventional histopathologic diagnosis. The results were recorded according to the non-epithelial or epithelial lesions, the benign or malignant lesions and the final diagnosis. According to the gold standard of histopathologic diagnosis, the results were analyzed.Results:In the diagnosis of epithelial or non-epithelial lesions, both fine needle aspiration biopsy processed by cytologic smear and cell block techniques can completely distinguish the non-epithelial lesions from epithelial lesions.In the diagnosis of benign and malignant lesions, The diagnostic sensitivities, specificities, and accuracies for distinguishing benign from malignant lesions were:cytologic smears-76%,68%, and71%, respectively; CB with immunohistochemical staining--88%,87%, and88%, respectively. Finally, in the final diagnosis, the diagnostic accuracy of CB method with immunostaining was higher than the fine needle aspiration cytology (p<0.05).Conclusion:FNAB of LLL processed using a CB technique capable of producing immunohistochemically stained slides results in a greater percentage of accurate tissue diagnoses than do cytologic smears, when compared to routine histopathology.