A Study Of ERCC1Singlenucleotide Polymorphism To The Effect Of Radiotherapy And Prognosisin In Aged Patients With Locally Advanced Non-small-cell Lung Cancer

Objective: To study the relationship betwee ERCC1rs3212986genepolymorphism to the effect of radiotherapy and prognosis in aged patientswith locally advanced Non-small-cell lung cancer.Methods:44aged patients with locally advanced NSCLC who onlyaccepted radiotherapy was aassayed its single nucleotide polymorphismsubtypes of ERCC1rs3212986by PCR-RFLP method,then the relationshipbetween SNP subtypes and its effect to radiotherapy and prognosis wasanalysed according to clinical and follow up data.Results: In the44cases,the ERCC1rs3212986subtypes distribution is5AA,19CA and20CC.After radiothrapy for only treatment the patients’total response rate is36.4%, those carrying at least one wild gene A(including CA and AA type) have a1.67times higher radiotherapyresponse rate than those was pure variant CC type(OR=1.667，95%CI=0.475-5.842，P=0.043)；The ERCC1rs3212986SNP did not show significent relation with radioactive esophageal injury or marrowsuppression during therapy in the study（P=0.141, P=0.298）.According toan analysis of follow-up data, the median survival period of CC genetype is11.0month(95%CI:9.945~12.055）,while the CA、AA genetype is14.0month(95%CI:11.687~16.313) and13.0month(95%CI:7.120~18.880)respectively,which were statistieally significant(P=0.002,P=0.032);carrying at least one wild gene A (including CA and AA type) have amedian survival period of14.0month(95%CI:11.326~16.674），alsosignificant longer than pure variant CC type’s11.0month（P=0.001）。Conclusion:1. Patients who carrying wild gene A of ERCC1rs3212986has a higher radiosencitivity than pure variant CC type；2.There is nosignificant relationship between ERCC1rs3212986SNP and radioactiveesophageal injury or marrow suppression occurred during radiotherapy；3.The SNP of ERCC1was closely correlated with prognosis, pure variant CCtype indicate an poorer prognosis.