Expression Of ERCC1,BRCA1 And Prognosis In Non-small Cell Lung Cancer Of Uygur Patients

Objective: To investigate the expression of ERCC1 and BRCA1 in advanced non-small cell lung cancer (NSCLC) of Uygur patients as well as its clinical survival time and prognostic significance. Methods: Expression of ERCC1 and BRCA1 in 27 cases paraffin-embedded pathological specimens and 53 cases formalin-fixed biopsy specimens of NSCLC Uygur patient was determined by Immunohistochemistry method in January 2004 to December 2008 in our hospital,furthermore to evaluat the value of each factors in the NSCLC survival analysis. SPSS 17.0 for windows software was used for statistics, x2test was used in the comparisons of rate, data were examined by Kaplan-Meier method and log-rank test. The Cox regression was used to evaluate the expression of ERCC1,BRCA1 and other related clinical factors influenced in survival rate. Results: In these 80 cases,positive expression rates of ERCC1 was 38.6% (31/80), and there were no correlation with patient age, gender, clinical stage and pathology, but were correlation with patient scor and smoking. Positive expression rates of BRCA1 was 88.8% (71/80), and there were no correlation with patient age, gender, smoking ,clinical stage and pathology, but was correlation with patient scor. The expression of ERCC1 and BRCA1 in median survival weeks were examined by Kaplan-Meier method,which was no significant difference between the two groups (P>0.05). The negative expression of ERCC1 has longer life than the positive ones,there was significant difference in survival rate of 1 year(P=0.035) . TNM stage and ages were Independent factors influenced in prognosis of NSCLC. Conclusion: The negative expression of ERCC1 could predict the sensitivity in advanced non-small cell lung cancer of Uygur patients.The expression of BRCA1 was no significant difference in NSCLC of Uygur patients. The result of this study may provide new sight for clinical therapy and decision prognosis to individual NSCLC Uygur patients.