| Objective：To detect C1q/TNF-related protein (CTRP)-3levels in healthy,obesityand type2diabetes mellitus (T2DM) subjects in Chongqing district and toinvestigate the association of plasma CTRP3levels with insulin resistanceindex and other related factors. Explor the possible mechanism of CTRP3effect in type2diabetes and obesity.Methods：The test included174subjects, Eighty-eight normal glucose tolerancepeople and eighty-six new diagnosed T2DM patients(the diagnosis criteriamade by WHO in1999). Normal weight (NW) and obese (OB) subgroupswere divided in each group when body mass index (BMI)≥25kg/m2. Everysubject was taken OGTT test. Analysed the relationships between plasmaCTRP3levels and fasting plasma glucose (FPG),2h plasma glucose(2hPG), HbA1C, fasting insulin (FINS), lipids and interleukin (IL)-6. BMI,waist-to-hip (WHR) and blood pressure were also evaluated. IR index was assessed by Homeostasis model assessment (HOMA).HOMA-IR=Fins×FPG/22.5. Plasma CTRP3and IL-6were detected byELISA.Results:(1) The levels of plasma CTRP3in T2DM group were significantlylower compared to NGT group[(369.59±117.56)vs(445.42±124.03)ng/mL，P<0.01], and plasma CTRP3concentration in OB subjects were alsosignificantly lower than those in NGT-NW and T2DM-NW subjects[(393.77±121.34)vs(494.77±106.14)ng/mLand(313.78±71.60)vs(430.83±127.98)ng/mL, P<0.01].(2) The single factor correlation analysis showedplasma CTRP3levels were not related to gender, age, blood pressure, TCand LDL-C (P>0.05), It was negatively related to BMI, WC, WHR, FPG,2hPG, HbA1c, TG, FINS (P<0.01), while positively related toHDL-C(P<0.05). Plasma CTRP3levels were still significantly negativelyrelated to HOMA-IR and IL-6even after BMI, WC, WHR were adjusted.(3) Multiple linear regression showed that HbA1c, TG and HOMA-IR wereindependently associated with plasma CTRP3levels (P <0.05).Conclusions：Plasma CTRP3levels were decreased in both obese and T2DMpatients compared to normal subjects, and it was correlated with obesity,glycolipid metabolism, inflammation and insulin resistance. HbA1c, TG andIR were independent factors affecting plasma CTRP3. Low CTRP3level could predict insulin resistance in patients with obese and T2DM. |
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