Clinical Research On Therapy Of Diabetic Peripheral Neuropathy Yin Deficiency And Blood Stasis Syndrome By Bai Wei Flavored Decoction

Purpose:To investigate the medical understanding of diabetic peripheral neuropathy(DPN), Bai Wei flavored decoction was observed by randomized controlled clinical trials.The indexes consist of blood glucose,glycated hemoglobin(HbAlc),syndromes points, neurological symptom points, blood rheology, EMG and other indicators. And to explore the mechanisms of prevention and treatment of DPN.Methods:By randomized parallel-group study method, DPN patients consistent with with Yin deficiency and blood stasis syndrome diagnostic standard, were randomly divided into the treatment group and the control group, based on the basic treatment,the control group were given Methycobal orally(methylcobalamin), the treatment groupwere given Methycobal (methyl cobalamin) with Bai Wei flavored decoction treatment orally. Treatment lasted for3months. Clinical symptoms,changes signs,blood sugar,glycosylated hemoglobin, blood rheology, EMG and other indicators were evaluated before and after treatment in both groups, as well as adverse reactions and compliance in patients.All data is analysised statistically through SPSS17.0statistical software.Results:The diagnosis and inclusion of60DPN patients with Yin deficiency and blood stasis syndrome (treatment group of30patients in the control group of30patients) was consisted of sex, age, duration of DPN and other basic data.Before the treatment,two groups showed no statistically significant difference,which was a comparable efficacy evaluation result:â‘ Improvement of symptoms and signs:after treatment, patients symptoms improved, the total effective rate was76.67%; the control group, the total efficiency of63.33%. Clinical symptoms and signs of patients treated were better than the control group (P<0.05).â‘¡Rheology:after treatment,compared to before treatment,the treatment group was significantly decreased whole blood viscosity (high cut, cut)(P<0.01), whole blood viscosity (low shear), compared with pre-treatment plasma viscosity decreased (P<0.05); controls the whole blood viscosity (high shear) lower than before treatment (P<0.05), the remaining lower obvious (P>0.05); between the two groups, the treatment group was more obvious, statistically significant (P<0.05).â‘¢EMG:After treatment, the treatment group median nerve,common peroneal nerve motor and sensory nerve conduction velocity was significantly increased comparing with that before treatment.The differences were statistically significant (P<0.01); median nerve controls the movement, sensory nerve conduction velocity, pre-treatment of the common peroneal nerve MNCV and somewhat obvious compared (P<0.05); SNCV improvement in the control group was significantly (P<0.01). Between the two groups, the treatment group median nerve and common peroneal nerve motor and sensory nerve conduction velocity improvement than the control group (P<0.01).â‘£Hypoglycemic effect:two fasting blood glucose (FBG),2-hour postprandial glucose (2hPBG), glycated hemoglobin (HbAlc) after treatment were not significantly different (P>0.05). There was no significant difference between groups (P>0.05).Conclusion:The clinical research from the perspective, combined Bai Wei flavored decoction with Methycobal therapy in patients with DPN,is better than western medicine alone (Methycobal) treatment.It shows that traditional Chinese medicine treatment not only can improve DPN symptoms of deficiency of blood stasis, signs,blood rheology, but also can improve nerve conduction velocity, and non-toxic side effects.Bai Wei flavored decoction has a certain value,which worthy of clinical application and in-depth study.