The Correlation Study Of NT-pro BNP In The Acute Exacerbation Of Chronic Obstructive Pulmonary Disease In Patients With Pulmonary Hypertension

Objective:To explore the clinical significance and correlation of amino terminal pro-brain natriuretic peptide (NT-Pro BNP) levels in the acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients with pulmonary hypertension (PH). Methods:126patients with AECOPD were measured systolic pulmonary artery pressure (SPAP) by echocardiography. They were divided into4groups according to SPAP: control group (≤30mmHg)41cases, mild PH group (31～50mmHg)33cases, moderate PH group (51～70mmHg)31cases and severe PH group (≤71mmHg)21cases. Serum NT-Pro BNP and arterial blood gas analysis were detected from all the selected patients. Results:Serum NT-Pro BNP [the moderate PH group:(982.10±389.90)pg/ml; the severe PH group:(1,677.83±467.78)pg/ml] and arterial partial pressure of carbondioxide (PaCO2)[the moderate ones:(46.98±6.56)mmHg; the severe ones:(53.22±5.29)mmHg] in moderate and severe PH group were significantly higher than the control [NT-Pro BNP:(174.84±33.66)pg/ml; PaCO2:(39.66±6.50)mmHg] and mild ones [NT-Pro BNP:(689.33±304.65)pg/ml; PaCO2:(40.45±9.84)mmHg]; while arterial partial pressure of oxygen (PaO2) in moderate and severe PH group [the moderate ones:(59.39±15.35)mmHg; the severe ones:(53.42±13.82)mmHg] were significantly lower than the control [(72.14±13.95)mmHg] and mild ones [(71.02±16.11)mmHg)]. NT-Pro BNP was observed a significant positive linear relationship between SPAP (r=0.35) and PaCO2(r=0.35), while PaO2was negatively correlated with NT-Pro BNP (r=-0.23). It was found that PaCO2had a significant positive linear relationship between SPAP (r=0.55), while PaO2was negatively correlated with SPAP (r=-0.42). Conclusion:Serum NT-Pro BNP levels are positively related to the SPAP, whose rising trend is in parallel with PaCO2, so it can be used as one of important indicators to judge the severity of PH in AECOPD patients.