Pathologic Factors Of Influencing The Staging Of Metastatic Lymph Nodes Ratio And Metastatic Lymph Nodes Number In Advanced Gastric Carcinoma

Objective To explore the association of pathologic facts with the staging of metastatic lymph nodes ratio (rN) or metastatic lymph nodes number (pN), and to provide evidence for reasonable tumor staging in advanced gastric carcinoma (AGC).Methods The clinical pathological data of555patients, who received radical resection for primary tumor of AGC between November2003and December2011at the first affiliated hospital of Xinjiang Medical University, were reviewed retrospectively. The relationships between and the clinical pathological factors influencing rN and pN were analyzed.Results Univariate analysis showed that differentiation degree, vascular cancer embolus, tumor diameter, gross type and invasion depth are significant association with rN or pN(all P<0.05); histological type was significant association rN(P<0.05), but not with pN. Logistic regression analysis revealed that vascular cancer embolus, tumor diameter and invasion depth were independent risk factor for lymph node distant metastasis in AGC(all P<0.05). ROC curves showed that rN was consistent with pN in evaluating the diagnostic value of tumor staging for lymph node distant metastasis in AGC.Conclusions Vascular cancer embolus, tumor diameter>4cm and invasion depth were independent risk factor for lymph node distant metastasis in AGC based on either metastatic lymph nodes ratio (rN) or metastatic lymph nodes number (pN). The rN staging is consistent with the pN staging in evaluating the diagnostic value of tumor staging for metastatic lymph node in AGC.