| Objective:To investigate the clinical curative effect of Azole phosphonic acid treat ment on Xinjiang Uyghur patients with postmenopausal osteoporosis. Method:A retrospective analysis of the119cases Uighur women with postmenopausal osteoporosis who were selected from Xinjiang Uygur Autonomous Region People’s Hospital from September2011to January2013.And they were no anti-osteoporosis treatment or other bone metabolic disease or drug. Divided into treatment and control groups according to the wishes of patients. There were69cases in treatment group,with an average age of60.4, and they were treated with5mg phosphonic acid in30min intravenous drip and oral calcium,600mg/d and alpha D30.25μg/d;50cases were in control group, with an average age of61.2, and oral calcium,600mg/d and alpha D30.25μg/d.Both groups were treated for12months Dual-energy X-ray absorptiometry (DEXA).DEXA was adopted to determine the mineral density valuesof1-4lumbar spine, femoral neck,Ward’s triangle bone in two groups pre-and post treatment. Results:The mineral density values of the treatment group patients in1-4lumbar spine,femoral neck,Ward’s triangle bone were higher than their pretreatment and were significantly higher than those of control group (P<0.05)。9patients in treatment group had influenza-like symptoms of fever, head-ache after the injection of azole phosphonic acid but relieved with non-steroidal anti-infla-mmatory drugs (NSAIDs) within3days,without kidney damage,gastrointestinal discom-fort and osteonecrosis. Conclusions:Azole phosphonic acid injection (5mg) can obviously improvethe bone mineral density in Uyghur postmenopausal women with osteoporosis,and adverse reactions can be tolerated.Therefore,it’s worthwhile to popularize and apply the treatment of Azole phosphonic acid injection in patients with postmenopausal osteoporosis... |
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